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PINK1/Parkin in Neurodegenerative Disorders: Crosstalk Between Mitochondrial Stress and Neurodegeneration

PINK1/Parkin in Neurodegenerative Disorders: Crosstalk Between Mitochondrial Stress and Neurodegeneration

Mukesh Pandey, Shakir Saleem, Himani Nautiyal, Faheem Hyder Pottoo, Md. Noushad Javed
Copyright: © 2020 |Pages: 20
ISBN13: 9781799813170|ISBN10: 1799813177|EISBN13: 9781799813187
DOI: 10.4018/978-1-7998-1317-0.ch011
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MLA

Pandey, Mukesh, et al. "PINK1/Parkin in Neurodegenerative Disorders: Crosstalk Between Mitochondrial Stress and Neurodegeneration." Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, IGI Global, 2020, pp. 282-301. https://doi.org/10.4018/978-1-7998-1317-0.ch011

APA

Pandey, M., Saleem, S., Nautiyal, H., Pottoo, F. H., & Javed, M. N. (2020). PINK1/Parkin in Neurodegenerative Disorders: Crosstalk Between Mitochondrial Stress and Neurodegeneration. In M. Uddin & G. Ashraf (Eds.), Quality Control of Cellular Protein in Neurodegenerative Disorders (pp. 282-301). IGI Global. https://doi.org/10.4018/978-1-7998-1317-0.ch011

Chicago

Pandey, Mukesh, et al. "PINK1/Parkin in Neurodegenerative Disorders: Crosstalk Between Mitochondrial Stress and Neurodegeneration." In Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, 282-301. Hershey, PA: IGI Global, 2020. https://doi.org/10.4018/978-1-7998-1317-0.ch011

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Abstract

PTEN-induced kinase 1 (PINK1), a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene, is thought to protect cells from stress-induced mitochondrial dysfunction. The activity of PINK1 facilitates the binding of Parkin protein with depolarized mitochondria to induce autophagy. Mutations of PINK1causes a type of autosomal recessive early-onset Parkinson's disease. Cell depends on the surveillance systems or mechanisms like protein quality control to handle the alterations in the proteins that are induced because of these mutations. These mutant proteins are found to be pathogenic and are reported to be related to various neurodegenerative disorders. This chapter focuses on the role of PINK1/Parkin in mitochondria quality control and its subsequent effect in neurodegeneration.

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