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Obstructions in Nanoparticles Conveyance, Nano-Drug Retention, and EPR Effect in Cancer Therapies

Obstructions in Nanoparticles Conveyance, Nano-Drug Retention, and EPR Effect in Cancer Therapies

Khalid Umar Fakhri, Armiya Sultan, Md Mushtaque, Mohammad Raghibul Hasan, Sana Nafees, Zubair Bin Hafeez, Md Zafaryab, Md Rizwanullah, Deepti Sharma, Farhad Bano, Waleed Hassan AlMalki, Farhan Jalees Ahmad, M. Moshahid Alam Rizvi
Copyright: © 2021 |Pages: 36
ISBN13: 9781799865308|ISBN10: 1799865304|EISBN13: 9781799865315
DOI: 10.4018/978-1-7998-6530-8.ch026
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MLA

Fakhri, Khalid Umar, et al. "Obstructions in Nanoparticles Conveyance, Nano-Drug Retention, and EPR Effect in Cancer Therapies." Handbook of Research on Advancements in Cancer Therapeutics, edited by Sumit Kumar, et al., IGI Global, 2021, pp. 669-704. https://doi.org/10.4018/978-1-7998-6530-8.ch026

APA

Fakhri, K. U., Sultan, A., Mushtaque, M., Hasan, M. R., Nafees, S., Hafeez, Z. B., Zafaryab, M., Rizwanullah, M., Sharma, D., Bano, F., AlMalki, W. H., Ahmad, F. J., & Rizvi, M. M. (2021). Obstructions in Nanoparticles Conveyance, Nano-Drug Retention, and EPR Effect in Cancer Therapies. In S. Kumar, M. Rizvi, & S. Verma (Eds.), Handbook of Research on Advancements in Cancer Therapeutics (pp. 669-704). IGI Global. https://doi.org/10.4018/978-1-7998-6530-8.ch026

Chicago

Fakhri, Khalid Umar, et al. "Obstructions in Nanoparticles Conveyance, Nano-Drug Retention, and EPR Effect in Cancer Therapies." In Handbook of Research on Advancements in Cancer Therapeutics, edited by Sumit Kumar, Moshahid Alam Rizvi, and Saurabh Verma, 669-704. Hershey, PA: IGI Global, 2021. https://doi.org/10.4018/978-1-7998-6530-8.ch026

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Abstract

In this chapter, the authors first review nano-devices that are mixtures of biologic molecules and synthetic polymers like nano-shells and nano-particles for the most encouraging applications for different cancer therapies. Nano-sized medications additionally spill especially into tumor tissue through penetrable tumor vessels and are then held in the tumor bed because of diminished lymphatic drainage. This procedure is known as the enhanced penetrability and retention (EPR) impact. Nonetheless, while the EPR impact is generally held to improve conveyance of nano-medications to tumors, it in certainty offers not exactly a 2-overlay increment in nano-drug conveyance contrasted with basic ordinary organs, bringing about medication concentration that is not adequate for restoring most malignant growths. In this chapter, the authors likewise review different obstructions for nano-sized medication conveyance and to make the conveyance of nano-sized medications to tumors progressively successful by expanding on the EPR impact..

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