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Inflammatory Pathways and In Vivo Studies of Inflammatory Bowel Disease

Inflammatory Pathways and In Vivo Studies of Inflammatory Bowel Disease

Daniela Ribeiro, Marisa Freitas, José Miguel P. Ferreira de Oliveira, M. Luisa Corvo, Félix Dias Carvalho, Eduarda Fernandes
Copyright: © 2021 |Pages: 23
ISBN13: 9781799835806|ISBN10: 1799835804|EISBN13: 9781799835813
DOI: 10.4018/978-1-7998-3580-6.ch001
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MLA

Ribeiro, Daniela, et al. "Inflammatory Pathways and In Vivo Studies of Inflammatory Bowel Disease." Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer, edited by Ashok Kumar Pandurangan, IGI Global, 2021, pp. 1-23. https://doi.org/10.4018/978-1-7998-3580-6.ch001

APA

Ribeiro, D., Freitas, M., Ferreira de Oliveira, J. M., Corvo, M. L., Carvalho, F. D., & Fernandes, E. (2021). Inflammatory Pathways and In Vivo Studies of Inflammatory Bowel Disease. In A. Pandurangan (Ed.), Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer (pp. 1-23). IGI Global. https://doi.org/10.4018/978-1-7998-3580-6.ch001

Chicago

Ribeiro, Daniela, et al. "Inflammatory Pathways and In Vivo Studies of Inflammatory Bowel Disease." In Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer, edited by Ashok Kumar Pandurangan, 1-23. Hershey, PA: IGI Global, 2021. https://doi.org/10.4018/978-1-7998-3580-6.ch001

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Abstract

Inflammatory bowel disease (IBD) is a physically incapacitating disorder that significantly disturbs patients' quality of life. IBD is classified into two main pathophysiological forms, ulcerative colitis and Crohn's disease. Literature studies indicate that chronic colitis may contribute to the development of up to 25% of all diagnosed colorectal tumors. The complexity and development of IBD onset is intermediated by a variety of inflammatory mediators and pathways that are intrinsically linked and are summarized in this chapter. This complexity resulted in the development of various in vivo models to surpass the enormous challenges in the finding of new drugs for IBD treatment. These models are mostly based on rodents and on three types of inflammatory activation: chemical induction, transfer of naïve CD4+ T cells, and generation of engineered mouse strains, with specific target gene manipulations. The most broadly described models in literature are here presented and discussed.

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