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Liver Injury in COVID-19 Patients: An Overview of the Current Evidence

Liver Injury in COVID-19 Patients: An Overview of the Current Evidence

Tiziano Balzano, Omar El Hiba, Natalia López-González del Rey, Souad El Amine, Kamal Smimih
Copyright: © 2022 |Pages: 18
ISBN13: 9781799882251|ISBN10: 179988225X|EISBN13: 9781799882268
DOI: 10.4018/978-1-7998-8225-1.ch009
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MLA

Balzano, Tiziano, et al. "Liver Injury in COVID-19 Patients: An Overview of the Current Evidence." Handbook of Research on Pathophysiology and Strategies for the Management of COVID-19, edited by Omar El Hiba, et al., IGI Global, 2022, pp. 141-158. https://doi.org/10.4018/978-1-7998-8225-1.ch009

APA

Balzano, T., El Hiba, O., López-González del Rey, N., El Amine, S., & Smimih, K. (2022). Liver Injury in COVID-19 Patients: An Overview of the Current Evidence. In O. El Hiba, J. Radhakrishnan, T. Balzano, & F. Isbaine (Eds.), Handbook of Research on Pathophysiology and Strategies for the Management of COVID-19 (pp. 141-158). IGI Global. https://doi.org/10.4018/978-1-7998-8225-1.ch009

Chicago

Balzano, Tiziano, et al. "Liver Injury in COVID-19 Patients: An Overview of the Current Evidence." In Handbook of Research on Pathophysiology and Strategies for the Management of COVID-19, edited by Omar El Hiba, et al., 141-158. Hershey, PA: IGI Global, 2022. https://doi.org/10.4018/978-1-7998-8225-1.ch009

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preferentially infects cells in the respiratory tract, but several studies have also demonstrated low levels of SARS-CoV-2 copies in the liver. The hypothesis that patients with COVID-19 may develop liver dysfunction is supported by findings showing abnormal liver test results in such patients, but the exact mechanisms by which SARS-CoV-2 induces liver damage remain unclear. Liver injury in COVID-19 patients has probably a multifactorial etiology including the rapid onset of a systemic pro-inflammatory state due to viral infection, the use of potentially hepatotoxic drugs, pneumonia-associated hypoxia, and the eventual direct injury of the liver by SARS-CoV-2. This chapter will discuss the potential pathophysiological mechanisms for SARS-CoV-2 hepatic tropism and an overview about the main biochemical and histopathological findings observed in liver from COVID-19 patients. Finally, the effects that this infection can produce in patients with chronic liver disease will be also discussed.

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