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Introduction to GRNs

Introduction to GRNs

Ugo Ala, Christian Damasco
Copyright: © 2010 |Pages: 29
ISBN13: 9781605666853|ISBN10: 1605666858|EISBN13: 9781605666860
DOI: 10.4018/978-1-60566-685-3.ch002
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MLA

Ala, Ugo, and Christian Damasco. "Introduction to GRNs." Handbook of Research on Computational Methodologies in Gene Regulatory Networks, edited by Sanjoy Das, et al., IGI Global, 2010, pp. 28-56. https://doi.org/10.4018/978-1-60566-685-3.ch002

APA

Ala, U. & Damasco, C. (2010). Introduction to GRNs. In S. Das, D. Caragea, S. Welch, & W. Hsu (Eds.), Handbook of Research on Computational Methodologies in Gene Regulatory Networks (pp. 28-56). IGI Global. https://doi.org/10.4018/978-1-60566-685-3.ch002

Chicago

Ala, Ugo, and Christian Damasco. "Introduction to GRNs." In Handbook of Research on Computational Methodologies in Gene Regulatory Networks, edited by Sanjoy Das, et al., 28-56. Hershey, PA: IGI Global, 2010. https://doi.org/10.4018/978-1-60566-685-3.ch002

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Abstract

The post-genomic era shifted the main biological focus from ‘single-gene’ to ‘genome-wide’ approaches. High throughput data available from new technologies allowed to get inside main features of gene expression and its regulation and, at the same time, to discover a more complex level of organization. Analysis of this complexity demonstrated the existence of nonrandom and well-defined structures that determine a network of interactions. In the first part of the chapter, we present a functional introduction to mechanisms involved in genes expression regulation, an overview of network theory, and main technologies developed in recent years to analyze biological processes are discussed. In the second part, we review genes regulatory networks and their importance in system biology.

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