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Theoretical Study on the Antioxidant Activity of Alizarin, Purpurin, and Pseudopurpurin

Theoretical Study on the Antioxidant Activity of Alizarin, Purpurin, and Pseudopurpurin

Ruifa Jin, Hongzheng Bao, Yin Bai, Xiuhua Li
Copyright: © 2011 |Pages: 11
ISBN13: 9781609600648|ISBN10: 1609600649|EISBN13: 9781609600662
DOI: 10.4018/978-1-60960-064-8.ch012
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MLA

Jin, Ruifa, et al. "Theoretical Study on the Antioxidant Activity of Alizarin, Purpurin, and Pseudopurpurin." Interdisciplinary Research and Applications in Bioinformatics, Computational Biology, and Environmental Sciences, edited by Limin Angela Liu, et al., IGI Global, 2011, pp. 130-140. https://doi.org/10.4018/978-1-60960-064-8.ch012

APA

Jin, R., Bao, H., Bai, Y., & Li, X. (2011). Theoretical Study on the Antioxidant Activity of Alizarin, Purpurin, and Pseudopurpurin. In L. Liu, D. Wei, & Y. Li (Eds.), Interdisciplinary Research and Applications in Bioinformatics, Computational Biology, and Environmental Sciences (pp. 130-140). IGI Global. https://doi.org/10.4018/978-1-60960-064-8.ch012

Chicago

Jin, Ruifa, et al. "Theoretical Study on the Antioxidant Activity of Alizarin, Purpurin, and Pseudopurpurin." In Interdisciplinary Research and Applications in Bioinformatics, Computational Biology, and Environmental Sciences, edited by Limin Angela Liu, Dongqing Wei, and Yixue Li, 130-140. Hershey, PA: IGI Global, 2011. https://doi.org/10.4018/978-1-60960-064-8.ch012

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Abstract

Hydroxyanthraquinone derivatives are a large group of natural polyphenolic compounds found widely in plants. The cytotoxic activities of hydroxyanthraquinone derivatives have been demonstrated using cancer cell lines. The pharmacological effect can be explained by their antioxidant activity and their inhibition of certain enzymes. There are two main kinds of mechanism, H-atom transfer and one-electron transfer, by which antioxidants can play their role. The structural and electronic properties of hydroxyanthraquinone derivatives, alizarin, purpurin, pseudopurpurin, and their radicals were investigated using density functional theory. It turned out that these three molecules appear to be good candidates for high antioxidant activity species, particularly for pseudopurpurin. Taking this system as an example, we present an efficient method for the investigation of antioxidant activity for such kind of hydroxyanthraquinone derivatives from theoretical point of view. With the current work, we hope to highlight the antioxidant activity of hydroxyanthraquinone derivatives and stimulate the interest for further studies and exploitation in pharmaceutical industry.

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