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Discovering Lethal Proteins in Protein Interaction Networks

Discovering Lethal Proteins in Protein Interaction Networks

Kar Leong Tew, Xiao-Li Li
Copyright: © 2009 |Pages: 20
ISBN13: 9781605663982|ISBN10: 1605663980|ISBN13 Softcover: 9781616925253|EISBN13: 9781605663999
DOI: 10.4018/978-1-60566-398-2.ch011
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MLA

Tew, Kar Leong, and Xiao-Li Li. "Discovering Lethal Proteins in Protein Interaction Networks." Biological Data Mining in Protein Interaction Networks, edited by Xiao-Li Li and See-Kiong Ng, IGI Global, 2009, pp. 183-202. https://doi.org/10.4018/978-1-60566-398-2.ch011

APA

Tew, K. L. & Li, X. (2009). Discovering Lethal Proteins in Protein Interaction Networks. In X. Li & S. Ng (Eds.), Biological Data Mining in Protein Interaction Networks (pp. 183-202). IGI Global. https://doi.org/10.4018/978-1-60566-398-2.ch011

Chicago

Tew, Kar Leong, and Xiao-Li Li. "Discovering Lethal Proteins in Protein Interaction Networks." In Biological Data Mining in Protein Interaction Networks, edited by Xiao-Li Li and See-Kiong Ng, 183-202. Hershey, PA: IGI Global, 2009. https://doi.org/10.4018/978-1-60566-398-2.ch011

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Abstract

This chapter introduces state-of-the-art computational methods which discover lethal proteins from Protein Interaction Networks (PINs). Lethal proteins are an interesting subject in understanding the minimal condition for cellular development and survival. A dysfunctional research subject or absence of a lethal protein would result in fatality of the cell. Biological experiments have been conducted to systematically detect such proteins. However, such processes are time consuming and requires huge amount of effort to conduct. The researchers have developed a series of computational methods which take advantage of the network properties of individual proteins to detect lethal proteins in PINs. In this chapter, each computational method is studied in depth with an analysis on its pros and cons. Finally, a discussion on the possible further research directions will conclude the chapter.

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