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Immunogenicity of Stem Cells

Immunogenicity of Stem Cells

Franz Ricklefs, Sonja Schrepfer
Copyright: © 2013 |Pages: 16
ISBN13: 9781466625068|ISBN10: 1466625066|EISBN13: 9781466625075
DOI: 10.4018/978-1-4666-2506-8.ch005
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MLA

Ricklefs, Franz, and Sonja Schrepfer. "Immunogenicity of Stem Cells." Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications, edited by Andriani Daskalaki , IGI Global, 2013, pp. 96-111. https://doi.org/10.4018/978-1-4666-2506-8.ch005

APA

Ricklefs, F. & Schrepfer, S. (2013). Immunogenicity of Stem Cells. In A. Daskalaki (Ed.), Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications (pp. 96-111). IGI Global. https://doi.org/10.4018/978-1-4666-2506-8.ch005

Chicago

Ricklefs, Franz, and Sonja Schrepfer. "Immunogenicity of Stem Cells." In Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications, edited by Andriani Daskalaki , 96-111. Hershey, PA: IGI Global, 2013. https://doi.org/10.4018/978-1-4666-2506-8.ch005

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Abstract

Current medical research is focused on two particular types of stem cells, adult stem cells and embryonic stem cells. Both cell types demonstrate a tremendous potential as the source for regenerative medicine due to their paracrine and pluripotency effects, respectively. Therefore, stem cells are expected to have an enormous impact on clinical therapy. However, allogeneic approaches using “off-the-shelf” stem cells from healthy donors are the only financially and ethically feasible pathway. The long-standing assumption that stem cells are not recognized by the recipient’s immune system was recently disproved not only by our group. Therefore, specific knowledge of the immunologic properties of pluripotent and multipotent stem cells is a prerequisite for safe applications of stem cell-based therapy. This chapter will discuss the involvement of the innate and adaptive immune system and summarize state-of-the art approaches to overcome the immunological barrier.

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