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3D Structural Bioinformatics of Proteins and Antibodies: State of the Art Perspectives and Challenges

3D Structural Bioinformatics of Proteins and Antibodies: State of the Art Perspectives and Challenges

Arianna Filntisi, Dimitrios Vlachakis, George Matsopoulos, Sophia Kossida
Copyright: © 2013 |Volume: 2 |Issue: 3 |Pages: 8
ISSN: 2160-9586|EISSN: 2160-9594|EISBN13: 9781466633643|DOI: 10.4018/ijsbbt.2013070105
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MLA

Filntisi, Arianna, et al. "3D Structural Bioinformatics of Proteins and Antibodies: State of the Art Perspectives and Challenges." IJSBBT vol.2, no.3 2013: pp.67-74. http://doi.org/10.4018/ijsbbt.2013070105

APA

Filntisi, A., Vlachakis, D., Matsopoulos, G., & Kossida, S. (2013). 3D Structural Bioinformatics of Proteins and Antibodies: State of the Art Perspectives and Challenges. International Journal of Systems Biology and Biomedical Technologies (IJSBBT), 2(3), 67-74. http://doi.org/10.4018/ijsbbt.2013070105

Chicago

Filntisi, Arianna, et al. "3D Structural Bioinformatics of Proteins and Antibodies: State of the Art Perspectives and Challenges," International Journal of Systems Biology and Biomedical Technologies (IJSBBT) 2, no.3: 67-74. http://doi.org/10.4018/ijsbbt.2013070105

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Abstract

Proteins are an important class of biochemical molecules, as the structural components of animal and human tissue are based on them. Antibodies are proteins that play a crucial role in the preservation of life since they are produced by the body's immune system as a response to harmful substances. The modelling of proteins and antibodies in particular is a vibrant research field which facilitates the design of drugs, a process otherwise demanding in terms of time and resources. A variety of computational methods and tools are being developed towards that goal, among which are hybrid quantum chemical/molecular mechanical methods and three-dimensional antibody modelling. In this review the authors discuss the knowledge concerning proteins and antibodies, as well as the use of quantum mechanics in the simulation of molecular systems and the three-dimensional antibody modelling.

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