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Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery

Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery

Sanjay Kumar Jain, Ankita Tiwari, Ankit Jain, Amit Verma, Shivani Saraf, Pritish Kumar Panda, Gaytri Gour
Copyright: © 2018 |Pages: 28
ISBN13: 9781522547815|ISBN10: 1522547819|EISBN13: 9781522547822
DOI: 10.4018/978-1-5225-4781-5.ch002
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MLA

Jain, Sanjay Kumar, et al. "Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery." Multifunctional Nanocarriers for Contemporary Healthcare Applications, edited by Md. Abul Barkat, et al., IGI Global, 2018, pp. 22-49. https://doi.org/10.4018/978-1-5225-4781-5.ch002

APA

Jain, S. K., Tiwari, A., Jain, A., Verma, A., Saraf, S., Panda, P. K., & Gour, G. (2018). Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery. In M. Barkat, H. A.B., S. Beg, & F. Ahmad (Eds.), Multifunctional Nanocarriers for Contemporary Healthcare Applications (pp. 22-49). IGI Global. https://doi.org/10.4018/978-1-5225-4781-5.ch002

Chicago

Jain, Sanjay Kumar, et al. "Application Potential of Polymeric Nanoconstructs for Colon-Specific Drug Delivery." In Multifunctional Nanocarriers for Contemporary Healthcare Applications, edited by Md. Abul Barkat, et al., 22-49. Hershey, PA: IGI Global, 2018. https://doi.org/10.4018/978-1-5225-4781-5.ch002

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Abstract

Numerous applications of colon-specific drug delivery have been found in a wide array of diseases like irritable bowel syndrome (IBS), inflammatory bowel diseases (ulcerative colitis and Crohn's disease), colorectal cancer, and diverticulitis. Drug delivery to the colon has different anatomic and pathophysiological barriers. In recent advancements, these barriers were overcome by using biodegradable polymeric nanoconstructs, which are exhibiting minimal systemic adverse effects. Various polymeric nanoconstructs (PNCs) such as nanoparticles, micelles, and dendrimers have been exploited for effective targeting to pathological sites of colon. PNCs on oral administration not only protect the bioactive from physicochemical degradation but also prevent premature leakage in the upper parts of gastrointestinal tract. The chapter summarizes various PNCs-based approaches for colon-specific drug delivery.

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