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Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease

Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease

Mansi Verma, Sujata Basu, Manisha Singh, Rachana R., Simrat Kaur, Neha Goel
Copyright: © 2020 |Pages: 23
ISBN13: 9781799813170|ISBN10: 1799813177|EISBN13: 9781799813187
DOI: 10.4018/978-1-7998-1317-0.ch008
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MLA

Verma, Mansi, et al. "Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease." Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, IGI Global, 2020, pp. 212-234. https://doi.org/10.4018/978-1-7998-1317-0.ch008

APA

Verma, M., Basu, S., Singh, M., R., R., Kaur, S., & Goel, N. (2020). Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease. In M. Uddin & G. Ashraf (Eds.), Quality Control of Cellular Protein in Neurodegenerative Disorders (pp. 212-234). IGI Global. https://doi.org/10.4018/978-1-7998-1317-0.ch008

Chicago

Verma, Mansi, et al. "Molecular Interactions of α-Synuclein, Mitochondria, and Cellular Degradation Pathways in Parkinson's Disease." In Quality Control of Cellular Protein in Neurodegenerative Disorders, edited by Md. Sahab Uddin and Ghulam Md. Ashraf, 212-234. Hershey, PA: IGI Global, 2020. https://doi.org/10.4018/978-1-7998-1317-0.ch008

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Abstract

Parkinson's disease (PD) has been reported to be the most common neurodegenerative diseases all over the world. Several proteins are associated and responsible for causing PD. One such protein is α-synuclein. This chapter discusses the role of α-synuclein in PD. Various genetic and epigenetic factors, which cause structural and functional changes for α-synuclein, have been described. Several molecular mechanisms, which are involved in regulating mitochondrial and lysosomal related pathways and are linked to α-synuclein, have been discussed in detail. The knowledge gathered is further discussed in terms of using α-synuclein as a diagnostic marker for PD and as a novel therapeutic target for the same.

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