Roles of Mitophagy in Cancer Regulation

Roles of Mitophagy in Cancer Regulation

Pages: 300
DOI: 10.4018/979-8-3693-3836-0
ISBN13: 9798369338360|EISBN13: 9798369338377
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Description & Coverage
Description:

Autophagy can selectively remove specific types of damaged or unnecessary mitochondria, known as mitochondria, and frees the cell's energy supply for use elsewhere. Also known as mitochondrial quality control, mitochondrial homeostasis is maintained by the practice of mitophagy. Following stress or injury, mitochondria self-based cells preserve their energy, not only by actively processing and removing damaged or lost molecules, but also by preventing their steady-state increases in reactive oxygen species from reaching damaging them. It has also been shown that mitophagy's influence on cell differentiation and development increases in recent studies, indicating that it has a more central role than previously thought in cellular activities. A better understanding of mitophagy understanding offers the possibility of elucidating human malignant disease, and carries significant promise for new treatments. In this issue, we would like to archive all of the research and review articles that how mitophagy is regulated in cancer.

The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. There are several labs that are focusing on the advancement in the field of mitophagy and cancer.

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Editor/Author Biographies

Ashok Kumar Pandurangan is an associate professor in School of Life Sciences, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, India. He pursued his PhD in the prestigious University of Madras, Guindy campus, Chennai, India in the area of natural products as a therapeutic agent for colorectal cancer. Later, he was postdoctoral researcher in Center for Cancer research, Children's Hospital Oakland Research Institute, Oakland, California, USA. Further he completed two postdoctoral research programs in Department of Nutrition and Dietetics, Universiti of Putra Malaysia and Department of Pharmacology, University of Malaya, Malaysia. He is currently interested to work in the area of colitis associated cancer (CAC) in murine model. Colitis associated cancer is very common nowadays in developing countries. Ulcerative Colitis (UC) is a type of Inflammatory Bowel Disease (IBD), if untreated can be a risk of developing as colitis associated cancer. Numerous studies are underway to identify drugs that control both inflammation and cell proliferation. So, he is interested in identify some novel drugs from natural source and elucidate the molecular mechanisms involved in the process of curing colitis associated cancer. He published several articles on the effects of natural agents in these areas of interest.

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