This document suggests the adoption of the Theory of Entrepreneurship by researchers who investigate the use of information systems by small businesses. The majority of existing research into this area tends to adopt results determined from investigations of larger businesses. Thus, the uniqueness of small business is not considered. Concepts such as strategic orientation, decision-making, and resource poverty contribute to the unique situation and approach taken by small business managers. The Theory of Entrepreneurship responds to these concepts. The framework suggests that organizations evolve and that entrepreneurs throughout this evolution face various challenges. The components of the Theory of Entrepreneurship are described here, in concert with the challenge to researchers to consider adopting this framework when conducting investigations into how information systems may be employed to support small business.