Application of Bayesian Network in Drug Discovery and Development Process

Application of Bayesian Network in Drug Discovery and Development Process

Arunkumar Chinnasamy (Bioinformatics Institute, Singapore), Sudhanshu Patwardhan (Bioinformatics Institute, Singapore) and Wing-Kin Sung (National University of Singapore, Singapore)
Copyright: © 2007 |Pages: 15
DOI: 10.4018/978-1-59904-141-4.ch012
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Abstract

The end of the 20th century and the advent of the new millennium have brought in a true merger of sciences for the benefit of mankind. The biggest promise it holds is that of improving the quality of human life by the discovery of newer medicines and better cures for diseases such as cancer and heart disease. Pharmaceutical companies and academic institutions alike have not failed to deliver on part of the promise by bringing out technologies and products that have significantly decreased mortality and morbidity associated with these diseases. An increase in the scale and complexity of the technologies has made it increasingly important to develop intelligent tools to analyze their output, and numerous mathematical and statistical techniques have been explored and exploited to do exactly this. Bayesian networks (BN) and similar graphical models for multivariate analysis are being used for analyzing these data with great success. They have made possible a high resolution insight into disease mechanisms like never before. These insights into the biological processes of health and disease have helped identify the appropriate targets for drug discovery and aided in the process of bringing better drugs faster to the market for patients in need. This chapter briefly explains the application and contribution of Bayesian networks to the drug discovery and development process.

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Table of Contents
Foreword
K. R. Rao
Chapter 1
Kaizhu Huang, Zenglin Xu, Irwin King, Michael R. Lyu, Zhangbing Zhou
Naive Bayesian network (NB) is a simple yet powerful Bayesian network. Even with a strong independency assumption among the features, it... Sample PDF
A Novel Discriminative Naive Bayesian Network for Classification
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Chapter 2
Ben K. Daniel, Juan-Diego Zapata-Rivera, Gordon I. McCalla
Bayesian belief networks (BBNs) are increasingly used for understanding and simulating computational models in many domains. Though BBN techniques... Sample PDF
A Bayesian Belief Network Approach for Modeling Complex Domains
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Chapter 3
Sachin Shetty, Min Song, Mansoor Alam
A Bayesian network model is a popular formalism for data mining due to its intuitive interpretation. This chapter presents a semantic genetic... Sample PDF
Data Mining of Bayesian Network Structure Using a Semantic Genetic Algorithm-Based Approach
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Chapter 4
Dimitris Margaritis, Christos Faloutsos, Sebastian Thrun
We present a novel method for answering count queries from a large database approximately and quickly. Our method implements an approximate DataCube... Sample PDF
NetCube: Fast, Approximate Database Queries Using Bayesian Networks
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Chapter 5
Helge Langseth, Luigi Portinale
Over the last decade, Bayesian networks (BNs) have become a popular tool for modeling many kinds of statistical problems. In this chapter we will... Sample PDF
Applications of Bayesian Networks in Reliability Analysis
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Chapter 6
Sumeet Gupta, Hee-Wong Kim
This chapter deals with the application of Bayesian modeling as a management decision support tool for management information systems (MIS)... Sample PDF
Application of Bayesian Modeling to Management Information Systems: A Latent Scores Approach
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Chapter 7
Andreas Savaki, Jiebo Luo, Michael Kane
Image understanding deals with extracting and interpreting scene content for use in various applications. In this chapter, we illustrate that... Sample PDF
Bayesian Networks for Image Understanding
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Chapter 8
Pedro M. Jorge, Arnaldo J. Abrantes, João M. Lemos, Jorge S. Marques
This chapter describes an algorithm for tracking groups of pedestrians in video sequences. The main difficulties addressed in this work concern... Sample PDF
Long Term Tracking of Pedestrians with Groups and Occlusions
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Chapter 9
Qian Diao, Jianye Lu, Wei Hu, Yimin Zhang, Gary Bradski
In a visual tracking task, the object may exhibit rich dynamic behavior in complex environments that can corrupt target observations via background... Sample PDF
DBN Models for Visual Tracking and Prediction
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Chapter 10
David Lo
In applications where the locations of human subjects are needed, for example, human-computer interface, video conferencing, and security... Sample PDF
Multimodal Human Localization Using Bayesian Network Sensor Fusion
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Chapter 11
C. Notarnicola
This chapter introduces the use of Bayesian methodology for inversion purposes: the extraction of bio-geophysical parameters from remotely sensed... Sample PDF
Retrieval of Bio-Geophysical Parameters from Remotely Sensing Data by Using Bayesian Methodology
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Chapter 12
Arunkumar Chinnasamy, Sudhanshu Patwardhan, Wing-Kin Sung
The end of the 20th century and the advent of the new millennium have brought in a true merger of sciences for the benefit of mankind. The biggest... Sample PDF
Application of Bayesian Network in Drug Discovery and Development Process
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Chapter 13
Seiya Imoto, Satoru Miyano
In cells, genes interact with each other and this system can be viewed as directed graphs. A gene network is a graphical representation of... Sample PDF
Bayesian Network Approach to Estimate Gene Networks
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Chapter 14
Vipin Narang, Rajesh Chowdhary, Ankush Mittal, Wing-Kin Sung
A predicament that engineers who wish to employ Bayesian networks to solve practical problems often face is the depth of study required in order to... Sample PDF
Bayesian Network Modeling of Transcription Factor Binding Sites: A Tutorial
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Chapter 15
Tie-Fei Liu, Wing-Kin Sung, Ankush Mittal
Exact determination of a gene network is required to discover the higher-order structures of an organism and to interpret its behavior. Currently... Sample PDF
Application of Bayesian Network in Learning Gene Network
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