Gradually, more institutions around the globe are becoming involved in dynamic change over a long period to provide time- and location-independent asynchronous e-learning opportunities. With the potential of network-based technologies, asynchronous e-learning has become a powerful, global, interactive, economic, and dynamic as well as democratic tool of virtual learning (Khan, 1997). Asynchronous e-learning provides an opportunity to build flexible online programs for sharing knowledge with virtual educational contents. To generate cogent asynchronous e-learning opportunities, however, it is important to analyze the principles, ethics, and pitfalls of sharing knowledge online between professionals and community. Therefore, asynchronous content must be designed carefully based on macro- and micro-level frameworks, which provide us with elaborating open, flexible, and distributed virtual learning milieus.