Large investments are being made to reform the health sector in developing countries as the potential of ICTs in achieving health goals is being increasingly recognized. However, there have been various reports that indicate this potential of ICT is not being fully realized on the ground in particular settings. In this chapter, an empirical investigation of the introduction of health information systems in the primary health-care sector in India is reported. Three cases—the India Health Care Project, Family Health Information Management System, and Integrated Health Information Management Systems—are presented. The authors argue against adopting a technocentric approach during the development of the HIS and suggest that these efforts should be sensitive to the sociotechnical context. Furthermore, a variety of constraints are identified. The chapter concludes with a discussion on the potentials of integration to address some of the identified constraints.