This chapter introduces critical success in supply chain implementation by empirical research. The widespread implementation of supply chain management induced companies to move beyond national borders and be enticed by the global competition in business. Applying supply chain management overall in organizations, companies generally considered it successful in managing their supply chains. However, some of them have not reached the magnitude of improvements or the desired results ascribed to supply chain management. With supply chain concerns and problems related to some basic companies’ infrastructures, the supply chain knowledge and operational skill affected the effectiveness of supply chain practices and performances. In this research, we studied the infrastructures enhancing the success of supply chain implementation that influence supply chain performance. The author adopts three categories of infrastructure as the critical success factors of supply chain implementation: man, machines, and management. The EQS is used to analyze the data collection. A total of 114 pieces of data were completed, and the result shows the significant relationship of operational infrastructures and the success of supply chain management.