The evaluation of information systems (ISs), especially in the healthcare field, is a complex task. Evidently, there is a need for better understanding of the different aspects evaluation. While in the general IS science field there have been several attempts to build frameworks and models to better understand the evaluation of ISs, in healthcare similar frameworks have been almost nonexistent. Unfortunately, general frameworks cannot be exactly applied for the cross-cultural evaluation of healthcare ISs, because they do not recognise the specific nature of the medicine. Based on works in different areas, this chapter represents an attempt at to combine them to conceptual frameworks for the evaluation of healthcare ISs.