This chapter introduces how culture impacts global knowledge sharing. Effective knowledge sharing (KS), one of the four interdependent dimensions of knowledge management (KM), is particularly important in today’s global environment in which national cultural differences are negotiated all the time. Knowledge sharing is described along six dimensions and national culture along four dimensions. A model is presented, which provides guidelines for effectively sharing different types of knowledge within different cultural environments. Several examples are presented to illustrate the model’s effectiveness. Using the model as a guide, the authors believe that decision makers will increase the chances that information and knowledge will be shared successfully.