In recent years, business practice has shown an interest in virtuality and virtual organizations as one of the responses to global-organizational development and company restructuring. High-tech environments demand continued innovations. The rational, authoritarian, bureaucratic organizations characterizing industrial and production-oriented companies are being rapidly replaced by the new, boundaryless, flexible, and high-technology-driven environments. Entrepreneurs respond to global opportunities, find partners, and build cross-border communication networks to link corporate processes and create empowered workplaces. A distinctive feature of these processes is the reliance on free-floating cybertrust where each partner is involved in decision-making processes and in building capabilities in continuously changing international markets. This chapter reflects on how contemporary entrepreneurs benefit from the high technology, virtuality, and cyber-culture of the modern organization. The findings draw attention to the technology-driven opportunism within virtual media and the role of entrepreneur within human–computer interaction. The chapter seeks to demystify views about organizations as virtual domains.