The ongoing tension between certainty over uncertainty is the main force that is driving the evidence-based medicine movement. The central philosophy of this practice lies in the idea that one can never take for granted one’s own practice, but by using a structured, problem-based approach, practitioners can logically manoeuvre their way through the obstacle course of clinical decision-making. Attending postgraduate educational events and reading various science journals are no longer sufficient to keep healthcare practitioners aware of all the new developments in practice. To gain this knowledge they need to accept that there are questions they have to ask about their practice. Having posed a number of questions, answers should be found to the most important, practitioners should appraise the quality of the resulting evidence and, if appropriate, practitioners should implement change in response to that new knowledge.