The concept and study of supply chains are nothing new. The concept of integrated supply chain environments (ISCE), however, has received increased study as of late. Technology has become the enabling factor for corporations to share information externally and to improve material flow within the supply chain. Many benefits can be realized from an integrated supply chain environment, including improved customer relations, cost reductions, and increased competitive advantage. Despite the potential benefits, there are many factors that lead to failed integrated supply chain implementations. Many of the major factors that lead to failure are not due to technological reasons but rather to the failure of the project team to recognize the complexities of the implementations of integrated supply chains. This chapter introduces the Interaction Approach methodology as a framework for analyzing supply chains in the hope of improving the design, development, and implementation of integrated supply chain environments.