In this millennium, global organizations will increasingly focus on the critical value of the cross-cultural communication process, efficiency, competence and the cost of doing business. In order to successfully communicate cross-culturally, knowledge and understanding of cultural factors such as values, attitudes, beliefs and behaviors should be acquired. Because culture is a powerful force that strongly influences communication behavior, culture and communication are inseparably linked. The objective of this chapter is to define the framework for a cross-cultural communication process, efficiency, and cost of doing business in a global economy. This task is very important for the promoting of global peace through trade, since it aims at understanding how to communicate successfully among different cultures from different civilizations. This understanding should minimize conflicts, increase international trade and investment, and facilitate the development of the global economy. The research method is based on the architectural design of a cross-cultural communication process and system and their quantitative analysis. Their attributes are estimated in a normative way on a scale from 1 to 5, where 5 is the best value. The attributes for two selected cultures (Western-West and Egyptian) are estimated by expert opinions.