The primary objective of the study presented in this chapter is to understand the dynamics of implementing an integrated information technology (IT) system designed to support the treatment of breast cancer. Preliminary findings permitted the identification of adoption and resistance factors at individual, professional, and organizational levels. These findings provided insight into the potential challenges to be faced in redesigning work processes in an inter-organizational setting. Significant adoption factors included individual participation in the project and a positive assessment of benefits of the system by both individuals and professional groups. Alternatively, the absence of a multidisciplinary committee, coupled with the complexity of the environment, the tasks, and the technology were among factors identified as troublesome. In terms of the dynamics of the process itself, our observations revealed that promoters adopted a contingent and political approach. While this strategy is usually considered appropriate in healthcare organizations, information generated by this study will allow for a better understanding of important factors and mechanisms to consider and address in subsequent phases of implementation.