This chapter presents the InteliWeb environment that combines agents, fuzzy logic, and student model to recognize aspects of student’ self-efficacy beliefs to improve the effectiveness of e-learning systems. The self-efficacy construct means the student’s belief on his/her own capacity of performing a task. This belief affects his/her behavior, motivation, affectivity, and the choices he/she makes. We use fuzzy theory for dealing with uncertainty in the assessment of the students and the incomplete knowledge about his/her self-efficacy. The InteliWeb offers instruction material on biological sciences.