Slideware such as PowerPoint might be the most common software used for e-learning, yet is remarkably understudied. We begin this chapter by summarizing and analyzing literature on slideware in e-learning. We also review the debate on the cognitive style of PowerPoint, partly in the context of educational technology research on whether media influence learning. Then, we discuss the limitations of slideware and suggest strategies to consider when designing e-learning with slideware. The strategies include: accounting for differences between designing for synchronous and asynchronous delivery; avoiding software “wizards”; using graphic design principles; and advocating simplicity. Finally, we discuss the economic implications of slideware in e-learning. If slideware is immensely common in e-learning, do universities and colleges need to invest in expensive course management systems (CMS)? We advocate that administrators research slideware use in their institutions to inform decisions about which CMS, if any, is needed.