Mobile applications today face the challenges of increasing information, diversity of users and user contexts, and ever-increasing variations in mobile computing platforms. They need to continue being a successful business model for service providers and useful to their user community in the light of these challenges. An appropriate representation of information is crucial for the agility, sustainability, and maintainability of the information architecture of mobile applications. This article discusses the potential of the Semantic Web (Hendler, Lassila, & Berners- Lee, 2001) framework to that regard. The organization of the article is as follows. We first outline the background necessary for the discussion that follows and state our position. This is followed by the introduction of a knowledge representation framework for integrating Semantic Web and mobile applications, and we deal with both social prospects and technical concerns. Next, challenges and directions for future research are outlined. Finally, concluding remarks are given.