In this chapter, we focus the role of information systems (IS) integration in the context of corporate mergers and acquisitions (M&As). We address the domain from a management perspective and especially target the consequences IS integration has for the acquisition initiative. Based on a literature review, the chapter presents a framework for describing, explaining and managing IS integration in M&As. The framework is suitable both for academics conducting scientific research on IS in M&As as well as business professionals considering an acquisition or merger. The usefulness and validity of the framework is shown by a case study: the Trelleborg Industrial Hose acquisition and IS integration. Based on the framework, the case and relevant literature lessons learned and future research needs are presented and discussed.