The topic of globalization is increasingly attracting the attention of software engineers, system researchers, and, most interestingly, business practitioners. In recent years there has been a perceptible increase in demand from business companies, services, and non-profit organizations and even from government bodies around the world to adopt and utilize Internet-based technologies in order to transform their traditional business/service activities into an electronic business environment. Such a transformation empowers organizations to expand their business processes beyond their local borders and move the entire business from localization to globalization. This chapter introduces and investigates the entire organizational transformation process to globalization. It starts with emphasizing the necessity of moving local businesses’ practices to a global market with the highlight of the major driving forces for globalization. Furthermore this chapter examines a number of vital issues that may strongly impact the final outcomes of the entire transformation process. These issues include main obstacles, resistance to change, and risk factors associated with the transformation process. Moreover this chapter proposes a conceptual framework with the objective of providing a good comprehension of the involved factors in transformation with their relationships. The last section of this chapter focuses on examining and exploring the foremost transformation maturity stages, readiness, adoption, diffusion, and retrospective.