Protein Interactions and DiseasesAthina Theodosiou (Biomedical Research Foundation of the Academy of Athens, Greece), Charalampos Moschopoulos (Biomedical Research Foundation of the Academy of Athens, Greece), Marc Baumann (Biomedicum, Helsinki University, Finland) and Sophia Kossida (Biomedical Research Foundation of the Academy of Athens, Greece)
Copyright © 2009. 20 pages.
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DOI: 10.4018/978-1-60566-076-9.ch039, ISBN13: 9781605660769, ISBN10: 1605660760, EISBN13: 9781605660776 Sample PDFCite Chapter
MLA
Theodosiou, Athina, Charalampos Moschopoulos, Marc Baumann and Sophia Kossida. "Protein Interactions and Diseases." Handbook of Research on Systems Biology Applications in Medicine. IGI Global, 2009. 694-713. Web. 23 May. 2012. doi:10.4018/978-1-60566-076-9.ch039
APA
Theodosiou, A., Moschopoulos, C., Baumann, M., & Kossida, S. (2009). Protein Interactions and Diseases. In A. Daskalaki (Ed.), Handbook of Research on Systems Biology Applications in Medicine (pp. 694-713). Hershey, PA: Medical Information Science Reference. doi:10.4018/978-1-60566-076-9.ch039
Chicago
Theodosiou, Athina, Charalampos Moschopoulos, Marc Baumann and Sophia Kossida. "Protein Interactions and Diseases." In Handbook of Research on Systems Biology Applications in Medicine, ed. Andriani Daskalaki , 694-713 (2009), accessed May 23, 2012. doi:10.4018/978-1-60566-076-9.ch039
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 | | TopAbstractIn previous years, scientists have begun understanding the significance of proteins and protein interactions. The direct connection of those with human diseases is now unquestionable and proteomics have become a scientific section of great research interest. In this chapter, we present a detailed description of the nature of protein interactions and describe the more important methodologies that are being used for their detection. Moreover, we review the mechanisms leading to diseases and involving protein interactions and refer to specific diseases such as Huntington’s disease and cancer. Lastly, we give an overview of the most popular computational methods that are used for the prediction or the healing of the diseases. TopComplete Chapter List|
1.
| Pathway Biology Approach to Medicine
(pages 1-10)
Peter Ghazal (University of Edinburgh Medical School, Scotland, and Centre for Systems Biology at Edinburgh, Scotland)
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| Systems and Control Theory for Medical Systems Biology
(pages 11-26)
Peter Wellstead (The Hamilton Institute, National University of Maynooth, Ireland), Sree Sreenath (Case Systems Biology Initiative, Case Western Reserve University, USA), Kwang-Hyun Cho (Korea Advanced Institute of Science and Technology (KAIST), Kor)
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| Mathematical Description of Time Delays in Pathways Cross Talk
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| Deterministic Modeling in Medicine
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| Synthetic Biology as a Proof of Systems Biology
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| Computational Models for the Analysis of Modern Biological Data
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| Computer Aided Knowledge Discovery in Biomedicine
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8.
| Function and Homology of Proteins Similar in Sequence: Phylogenetic Profiling
(pages 143-166)
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9.
| Computational Methods for the Prediction of GPCRs Coupling Selectivity
(pages 167-181)
Nikolaos G. Sgourakis (Rensselaer Polytechnic Institute, USA), Pantelis G. Bagos (University of Central Greece, and University of Athens, Greece), Stavros J. Hamodrakas (University of Athens, Greece)
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10.
| Bacterial ß-Barrel Outer Membrane Proteins: A Common Structural Theme Implicated in a Wide Variety of Functional Roles
(pages 182-207)
Pantelis G. Bagos (University of Central Greece, and University of Athens, Greece), Stavros J. Hamodrakas (University of Athens, Greece)
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11.
| Clustering Methods for Gene-Expression Data
(pages 209-220)
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12.
| Uncovering Fine Structure in Gene Expression Profile by Maximum Entropy Modeling of cDNA Microarray Images and Kernel Density Methods
(pages 221-238)
George Sakellaropoulos (University of Patras, Greece), Antonis Daskalakis (University of Patras, Greece), George Nikiforidis (University of Patras, Greece), Christos Argyropoulos (University of Pittsburgh Medical Center, USA)
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13.
| Gene Expression Profiling with the BeadArrayTM Platform
(pages 239-250)
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14.
| The Affymetrix GeneChip® Microarray Platform
(pages 251-261)
Djork-Arné Clevert (Charité Universitaetsmedizin Berlin, Germany and Johannes Kepler University Linz, Austria), Axel Rasche (Max-Planck-Institute for Molecular Genetics, Germany)
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15.
| Alternative Isoform Detection Using Exon Arrays
(pages 262-277)
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16.
| Gene Expression in Microbial Systems for Growth and Metabolism
(pages 278-290)
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17.
| Alternative Splicing and Disease
(pages 291-310)
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18.
| Mathematical Modeling of the Aging Process
(pages 312-330)
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19.
| The Sebaceous Gland: A Model of Hormonal Aging
(pages 331-337)
Evgenia Makrantonaki (Dessau Medical Center, Germany and Charité Universitaetsmedizin Berlin, Germany)
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20.
| Systems Biology Applied to Cancer Research
(pages 339-353)
R. Seigneuric (GROW Research Institute, University of Maastricht, The Netherlands), N.A.W. van Riel (Eindhoven University of Technology, The Netherlands), M.H.W. Starmans (GROW Research Institute, University of Maastricht, The Netherlands), A. van Erk (University)
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21.
| Systems Biology Strategies in Studies of Energy Homeostasis In Vivo
(pages 354-360)
Matej Orešic (VTT Technical Research Centre of Finland, Finland), Antonio Vidal-Puig (Institute of Metabolic Science, Addenbrooke’s Hospital, UK)
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22.
| Approaching Type 2 Diabetes Mellitus by Systems Biology
(pages 361-376)
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23.
| Systems Biology and Infectious Diseases
(pages 377-402)
Alia Benkahla (Institut Pasteur de Tunis, Tunisia), Lamia Guizani-Tabbane (Institut Pasteur de Tunis, Tunisia), Ines Abdeljaoued-Tej (ESSAI-UR Algorithmes et Structures, Tunisia), Slimane Ben Miled (Institut Pasteur de Tunis, Tunisia and ENIT-LAMSIN, Tunisia), Koussay Dellagi (Institut Pasteur de Tu)
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24.
| Systems Biology of Human-Pathogenic Fungi
(pages 403-421)
Daniela Albrecht (Leibniz Institute for Natural Product Research and Infection Biology -Hans-Knoell-Institute (HKI), Germany), Reinhard Guthke (Leibniz Institute for Natural Product Research and Infection Biology -Hans-Knoell-Institute)
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25.
| Development of Specific Gamma Secretase Inhibitors
(pages 423-437)
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26.
| In Machina Systems for the Rational De Novo Peptide Design
(pages 438-457)
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27.
| Applications of Metabolic Flux Balancing in Medicine
(pages 458-474)
Ferda Mavituna (The University of Manchester, UK), Raul Munoz-Hernandez (The University of Manchester, UK), Ana Katerine de Carvalho Lima Lobato (Federal University of Rio Grande do Norte, Brazil, and Potiguar University, Brazil)
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28.
| Multi-Level Data Integration and Data Mining in Systems Biology
(pages 476-496)
Roberta Alfieri (CNR - Institute for Biomedical Technologies, Italy and CILEA, Italy), Luciano Milanesi (CNR - Institute for Biomedical Technologies, Italy)
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29.
| Methods for Reverse Engineering of Gene Regulatory Networks
(pages 497-515)
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30.
| Data Integration for Regulatory Gene Module Discovery
(pages 516-529)
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31.
| Discrete Networks as a Suitable Approach for the Analysis of Genetic Regulation
(pages 530-540)
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32.
| Investigating the Collective Behavior of Neural Networks: A Review of Signal Processing Approaches
(pages 541-555)
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33.
| The System for Population Kinetics: Open Source Software for Population Analysis
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34.
| Photosynthesis: How Proteins Control Excitation Energy Transfer
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35.
| Photodynamic Therapy: A Systems Biology Approach
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36.
| Modeling of Porphyrin Metabolism with PyBioS
(pages 643-654)
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37.
| Interference Microscopy for Cellular Studies
(pages 656-672)
Alexey R. Brazhe (Technical University of Denmark, Denmark and Moscow State University, Russia), Nadezda A. Brazhe (Technical University of Denmark, Denmark and Moscow State University, Russia), Alexey N. Pavlov (Saratov State University, Russia), Georgy V. Maksimov (Moscow Sta)
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38.
| Fluorescence Imaging of Mitochondrial Long-Term Depolarization in Cancer Cells Exposed to Heat-Stress
(pages 673-692)
Cathrin Dressler (Laser- und Medizin-Technologie GmbH, Berlin, Germany), Olaf Minet (Charité Universitaetsmedizin Berlin, Germany), Urszula Zabarylo (Charité Universitaetsmedizin Berlin, Germany), Jürgen Beuthan (Charité Universitaetsmedizin Berlin, Germany)
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39.
| Protein Interactions and Diseases
(pages 694-713)
Athina Theodosiou (Biomedical Research Foundation of the Academy of Athens, Greece), Charalampos Moschopoulos (Biomedical Research Foundation of the Academy of Athens, Greece), Marc Baumann (Biomedicum, Helsinki University, Finland), Sophia Kossida (Biomedical Research Foundation of the Academy of Athens, Greece)
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40.
| The Breadth and Depth of BioMedical Molecular Networks: The Reactome Perspective
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41.
| Entropy and Thermodynamics in Biomolecular Simulation
(pages 731-758)
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42.
| Model Development and Decomposition in Physiology
(pages 759-797)
Isabel Reinecke (Zuse Institute Berlin, Germany), Peter Deuflhard (Zuse Institute Berlin, Germany)
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43.
| A Pandemic Avian Influenza Mathematical Model
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44.
| Dengue Fever: A Mathematical Model with Immunization Program
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45.
| Automated Image Analysis Approaches in Histopathology
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