Shopping Cart | Login | Register | Language: English

Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography

Copyright © 2011. 11 pages.
OnDemand Chapter PDF Download
Download link provided immediately after order completion
$30.00
List Price: $37.50
Current Promotions:
20% Online Bookstore Discount*
Available. Instant access upon order completion.
DOI: 10.4018/978-1-60960-559-9.ch029
Sample PDFCite

MLA

Tashiro, Manabu, Nobuyuki Okamura, Shoichi Watanuki, Shozo Furumoto, Katsutoshi Furukawa, Yoshihito Funaki, Ren Iwata, Yukitsuka Kudo, Hiroyuki Arai, Hiroshi Watabe and Kazuhiko Yanai. "Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography." Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications. IGI Global, 2011. 220-230. Web. 24 Oct. 2014. doi:10.4018/978-1-60960-559-9.ch029

APA

Tashiro, M., Okamura, N., Watanuki, S., Furumoto, S., Furukawa, K., Funaki, Y., Iwata, R., Kudo, Y., Arai, H., Watabe, H., & Yanai, K. (2011). Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography. In J. Wu (Ed.), Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications (pp. 220-230). Hershey, PA: Medical Information Science Reference. doi:10.4018/978-1-60960-559-9.ch029

Chicago

Tashiro, Manabu, Nobuyuki Okamura, Shoichi Watanuki, Shozo Furumoto, Katsutoshi Furukawa, Yoshihito Funaki, Ren Iwata, Yukitsuka Kudo, Hiroyuki Arai, Hiroshi Watabe and Kazuhiko Yanai. "Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography." In Early Detection and Rehabilitation Technologies for Dementia: Neuroscience and Biomedical Applications, ed. Jinglong Wu, 220-230 (2011), accessed October 24, 2014. doi:10.4018/978-1-60960-559-9.ch029

Export Reference

Mendeley
Favorite
Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography
Access on Platform
Browse by Subject
Top

Abstract

These findings suggest that [11C]BF-227 is a promising PET probe for clinical evaluation of early Aß deposition in AD patients.
Chapter Preview

Introduction

Positron Emission Tomography

Positron emission tomography (PET) is a technique used for functional and molecular imaging based on nuclear medicine technology. Nuclear medicine techniques date back to the early 20th century. Nuclear medicine was originally developed as a “tracer technique” by the Nobel laureate, Dr. George de Hevesy. In our study, the term “tracer” means an extremely small amount of radioisotope that is administered to the subject to permit imaging certain biological phenomena in the living body. A tracer is sometimes also called a “probe”. Probes detect the presence of a certain biological substances in small amounts (often at the “nano-” to “pico-” molar scale) (Tashiro, 2010). The tracer technique was later established as a nuclear medicine technique in the late 20th century, mainly due to advancements in radiolabeling techniques and signal detection devices such as PET.

Using PET, a wide range of biological information can be obtained from the living human brain, such as the cerebral metabolic rate of glucose (CMRglc), regional cerebral blood flow (rCBF) and pharmacokinetic information regarding receptor-transmitter interactions such as those in the dopaminergic and histaminergic neuronal systems (Yanai & Tashiro, 2007; Tashiro, 2010). CMRglc is often measured using a radioactive analogue of glucose, [18F]fluorodeoxyglucose ([18F]FDG). In brain regions that have increased glucose consumption, an increased demand for glucose and oxygen causes dilation of cerebral capillaries, which can be measured as an increase in the regional cerebral blood flow (rCBF)(Tashiro, 2008). The rCBF is measured using radiolabeled water ([15O]H2O), though other radiation-free techniques, such as functional magnetic resonance imaging (fMRI) and near-infrared light spectroscopy (NIRS), are also available. Currently, PET is useful for visualization and quantification of various molecular phenomena, such as neurotransmission, DNA synthesis, and production of physiological and pathological proteins, in living organisms. To our knowledge, PET is one of the most sensitive imaging techniques. (Figure 1)

Figure 1.

Information available from the human brain. Information regarding glucose and oxygen metabolism obtained using [18F]FDG PET and [15O]O2 PET. Currently, regional cerebral blood flow is measured using various methods, such as [15O]H2O PET, functional MRI (fMRI) and near infrared light spectroscopy (NIRS). Interaction of neurotransmitters and receptors is measured using PET and various radiotracers labeled with 18F and 11C nuclides.

In Japan, the incidence of cognitive disorders is increasing at an accelerated pace, partly due to the increasing size of the elderly population. Basic and clinical studies on dementia have become increasingly important. In functional neuroimaging of early Alzheimer's disease (AD), it is commonly known that a decrease in the CMRglc often starts in the posterior cingulate gyrus and propagates to the temporo-parietal and other regions, as visualized by [18F]FDG PET (Minoshima, 1994; Furukawa, 2009; Ishii, 2009). In this stage of dementia, many nerve cells are damaged and the density of healthy neurons is reduced in the gray matter, resulting in low [18F]FDG uptake. However, the regional metabolic reduction is not easily detected and is widespread during early disease stages, e.g., mild cognitive impairment (MCI)(Furukawa, 2009; Ishii, 2009). Neuronal damage is associated with high deposition of amyloid β (Aβ) protein in the brain, and massive neuronal loss is often preceded by high Aβ deposition. An early diagnosis of mild AD can be established if a tracer that specifically binds to Aβ proteins is used.

Top

Complete Chapter List

Search this Book: Reset
Table of Contents
Preface
Jinglong Wu
Chapter 1
Kaechang Park, Yinlai Jiang, Shuoyu Wang
This chapter examines the relationship between leukoaraiosis (LA) and visual interpolation ability (VIA) in healthy subjects using a novel method... Sample PDF
The Relationship between Visual Interpolation Ability and Leukoaraiosis in Healthy Subjects
$30.00
List Price: $37.50
Chapter 2
Tetsuo Kobayashi
This chapter introduces a newly developed integrative fMRI-MEG method combined with a spatial filtering (beamforming) technique as a non-invasive... Sample PDF
Integrative fMRI-MEG Methods and Optically Pumped Atomic Magnetometers for Exploring Higher Brain Functions
$30.00
List Price: $37.50
Chapter 3
Tianyi Yan, Jinglong Wu
In humans, functional imaging studies have found a homolog of the macaque motion complex, MT+, which is suggested to contain both the middle... Sample PDF
Location and Functional Definition of Human Visual Motion Organization Using Functional Magnetic Resonance Imaging
$30.00
List Price: $37.50
Chapter 4
Shuo Zhao, Chunlin Li, Jinglong Wu, Hongbin Han, Dehua Chui
Visual orienting attention is best studied using visual cues. Spatial and temporal attention have been compared using brain-imaging data. This... Sample PDF
Visual Attention with Auditory Stimulus
$30.00
List Price: $37.50
Chapter 5
Xiujun Li, Chunlin Li, Jinglong Wu, Qiyong Guo
Recent event-related fMRI studies suggest that a left-lateralized network exists for reading Chinese words (to contrast two-character Chinese words... Sample PDF
Cerebral Network for Implicit Chinese Character Processing: An fMRI Study
$30.00
List Price: $37.50
Chapter 6
Chunlin Li, Xiujun Li, Jinglong Wu, Hiroshi Kusahara
The authors of this chapter studied behavioral performance and brain activities associated with word priming using a Japanese Word Stem Completion... Sample PDF
Neuronal Substrates for Language Processing and Word Priming
$30.00
List Price: $37.50
Chapter 7
Shozo Tobimatsu
There are two major parallel pathways in humans: the parvocellular (P) and magnocellular (M) pathways. The former has excellent spatial resolution... Sample PDF
Visual Gnosis and Face Perception
$30.00
List Price: $37.50
Chapter 8
Kouji Nagashima, Jinglong Wu, Satoshi Takahashi
Sound localization ability differs among people, such as between a young person, a senior citizen, and a dementia patient. Therefore, it is possible... Sample PDF
Human Characteristics of Sound Localization under Masking for the Early Detection of Dementia
$30.00
List Price: $37.50
Chapter 9
Hidenori Hiraki, Satoshi Takahashi, Jinglong Wu
Dynamic perimetry is the area in which a subject is able to recognize a moving target by eye. It is used in medical tests to diagnose glaucoma and... Sample PDF
Kinetic Visual Field with Changing Contrast and Brightness
$30.00
List Price: $37.50
Chapter 10
Qi Li, Naoya Nakamura, Jinglong Wu, Yasuyuki Ohta, Koji Abe
With the rapid increase in the number of elderly people, the number of people with dementia is also increasing. The most common form of dementia is... Sample PDF
Effects of Stimulus Complexity on Bisensory Audiovisual Integration
$30.00
List Price: $37.50
Chapter 11
Jiajia Yang, Takashi Ogasa, Jinglong Wu, Yasuyuki Ohta, Koji Abe
The cognitive symptoms in early Alzheimer’s disease (AD) involve problems with learning, memory or planning. Currently, no medical tests are... Sample PDF
Tactile Pattern Delivery Device to Investigate Cognitive Mechanisms for Early Detection of Alzheimer’s Disease
$30.00
List Price: $37.50
Chapter 12
Nobuko Ota, Shinichiro Maeshima, Aiko Osawa, Miho Kawarada, Jun Tanemura
The authors of this chapter studied the prospective memory (PM) performance of 20 older people using the message task in delayed recall from the... Sample PDF
Prospective Memory Impairment in Remembering to Remember in Mild Cognitive Impairment and Healthy Subjects
$30.00
List Price: $37.50
Chapter 13
Hikaru Nakamura
The author of this chapter present six years of longitudinal data on Mini-Mental State Examination (MMSE) scores in Japanese patients with... Sample PDF
Cognitive Decline in Patients with Alzheimer’s Disease: A Six-Year Longitudinal Study of Mini-Mental State Examination Scores
$30.00
List Price: $37.50
Chapter 14
Shouzi Zhang, Qinyun Li, Maolong Gao
The purpose of this study was to evaluate the clinical effects of a combination of Huperzine A and memantine for the treatment of Alzheimer’s... Sample PDF
The Clinical Analysis of Combined Effects of Huperzine A and Memantine for Alzheimer’s Disease
$30.00
List Price: $37.50
Chapter 15
Yong Shen
Alzheimer’s disease (AD) is a constantly progressive and highly complex neurodegenerative disease, and there are many ways to molecularly... Sample PDF
From Bench to Bedside: BACE1, Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1, From Basic Science to Clinical Investigation
$30.00
List Price: $37.50
Chapter 16
Hiroshi Mori
Alzheimer’s disease (AD), the most prevalent disease of aged people, is a progressive neurodegenerative disorder with dementia. Amyloid-ß (also... Sample PDF
Aß Monomer, Oligomer and Fibril in Alzheimer's Disease
$30.00
List Price: $37.50
Chapter 17
Hideaki Tanaka
There is growing interest in the discovery of clinically useful, robust biomarkers for Alzheimer’s disease (AD) and pre-AD; the ability to... Sample PDF
The Value of Quantitative EEG Measures in the Early Diagnosis of Alzheimer’s Disease
$30.00
List Price: $37.50
Chapter 18
Apraxia  (pages 141-144)
Mark Hallett
Apraxia is the inability to perform skilled and/or learned movements, not explainable on the basis of more elemental abnormalities. There are... Sample PDF
Apraxia
$30.00
List Price: $37.50
Chapter 19
Hiroshi Watabe, Keisuke Matsubara, Yoko Ikoma
Positron emission tomography (PET) is an imaging technology used to visualize distribution of particular ligands inside living organisms. The ligand... Sample PDF
Pharmacokinetic Challenges against Brain Diseases with PET
$30.00
List Price: $37.50
Chapter 20
Takao Yamasaki, Shozo Tobimatsu
To elucidate how the dorsal visual pathway is functionally altered in mild cognitive impairment (MCI) and Alzheimer’s disease (AD) patients, first... Sample PDF
Motion Perception in Healthy Humans and Cognitive Disorders
$30.00
List Price: $37.50
Chapter 21
Yoshiki Takeuchi, Yoshiki Matsumoto, Takanori Miki, Katsuhiko Warita, Zhi-Yu Wang, Tomiko Yakura, Jun-Qian Liu
Neuronal transcytosis was observed at the stage when no neurotransmitter was released after the injection of wheat germ agglutinin-conjugated... Sample PDF
Neuronal Transcytosis of WGA Conjugated Protein: A New Approach to Amyloid-ß In Vivo
$30.00
List Price: $37.50
Chapter 22
Masayuki Karaki, Eiji Kobayashi, Ryuichi Kobayashi, Kosuke Akiyama, Tetsuo Toge, Nozomu Mori
Olfactory dysfunction is a frequent non-motor symptom in Parkinson’s disease (PD). This symptom is considered to be an early manifestation of the... Sample PDF
Functional Optical Hemodynamic Imaging of the Olfactory Cortex in Patients with Parkinson’s Disease
$30.00
List Price: $37.50
Chapter 23
Shun’ichi Doi, Takahiro Wada, Eiji Kobayashi, Masayuki Karaki, Nozomu Mori
As a result, it is verified that not only characteristics of the scent but also the driver’s preference and subjective judgment of scent changes... Sample PDF
Basic Study on the Effect of Scent on Arousal Level Using Multi-Channel Near-Infrared Spectroscopy (MNIRS)
$30.00
List Price: $37.50
Chapter 24
Shohei Kato, Sachio Hanya, Akiko Kobayashi, Toshiaki Kojima, Hidenori Itoh, Akira Homma
This chapter presents a novel approach for early detection of cognitive impairment in the elderly. The approach incorporates the use of speech sound... Sample PDF
A Speech Prosody-Based Approach to Early Detection of Cognitive Impairment in Elderly Subjects: A Preliminary Study
$30.00
List Price: $37.50
Chapter 25
Mayumi Oyama-Higa, Tiejun Miao, Yoko Hirohashi, Yuko Mizuno-Matsumoto
The authors of this chapter measured plethysmography and calculated the Largest Lyapunov Expornent (LLE) using non-linear analysis. They found that... Sample PDF
Non-Linear Analysis of Plethysmograms and the Effect of Communication on Dementia in Elderly Individuals
$30.00
List Price: $37.50
Chapter 26
Kei Yamada, Kentaro Akazawa, Tsunehiko Nishimura
Magnetic resonance MR tractography based on diffusion tensor imaging (DTI) was first introduced to the medical imaging community a decade ago. Since... Sample PDF
Diffusion Tensor Imaging for Dementia
$30.00
List Price: $37.50
Chapter 27
Yu Jia, Zheng Chen, Jiangyang Lu, Liu Tingting, Zhou Liang, Liu Xinying, Sun Miao, Weizhong Xiao, Dongsheng Fan, Chui Dehua
The current knowledge base on circulating serum and plasma risk factors of the cognitive decline of degenerative Alzheimer’s Disease is linked to... Sample PDF
The Important Role of Lipids in Cognitive Impairment
$30.00
List Price: $37.50
Chapter 28
Nobuyuki Okamura, Shozo Furumoto, Manabu Tashiro, Katsutoshi Furukawa, Hiroyuki Arai, Yukitsuka Kudo, Kazuhiko Yanai
Alzheimer’s disease (AD) and many other neurodegenerative disorders belong to the family of protein misfolding diseases. These diseases are... Sample PDF
Noninvasive Detection of Misfolded Proteins in the Brain Using [11C]BF-227 PET
$30.00
List Price: $37.50
Chapter 29
Manabu Tashiro, Nobuyuki Okamura, Shoichi Watanuki, Shozo Furumoto, Katsutoshi Furukawa, Yoshihito Funaki, Ren Iwata, Yukitsuka Kudo, Hiroyuki Arai, Hiroshi Watabe, Kazuhiko Yanai
These findings suggest that [11C]BF-227 is a promising PET probe for clinical evaluation of early Aß deposition in AD patients. Sample PDF
Quantitative Analysis of Amyloid ß Deposition in Patients with Alzheimer’s Disease Using Positron Emission Tomography
$30.00
List Price: $37.50
Chapter 30
Hidenao Fukuyama
The diagnosis of Alzheimer’s disease (AD) is often based on clinical and pathological data. Positron emission tomography (PET) using the tracer... Sample PDF
Neuroimaging in Alzheimer’s Disease
$30.00
List Price: $37.50
Chapter 31
Jinho Kim, Yong Jeong
Recently, various in vivo optical brain imaging techniques have been developed. Here, the authors introduce some of these systems and their... Sample PDF
In Vivo Optical Imaging of Brain and its Application in Alzheimer’s Disease
$30.00
List Price: $37.50
Chapter 32
Makoto Suzuki, Hikari Kirimoto, Atsushi Inamura, Yoshitsugu Omori, Sumio Yamada
The purpose of this study was to examine the test-retest reliability of hand-held dynamometer measurements in patients with dementia and determine... Sample PDF
The Relationship between Knee Extension Strength and Activities of Daily Living in Patients with Dementia
$30.00
List Price: $37.50
Chapter 33
Yuki Tanaka, Hiroki Nogawa, Hiroshi Tanaka
Our results show that dementia patients tend to judge Japanese music as being played in a major key, while healthy subjects judged these songs as... Sample PDF
Music Therapy for Dementia Patients: Tuned for Culture Difference
$30.00
List Price: $37.50
Chapter 34
Tetsuo Touge, Shin Morita, Eiji Yamada, Takashi Kusaka
The objective of this study was to elucidate the mechanism of transcranial magnetic stimulation (TMS) with maximum voluntary muscle contraction... Sample PDF
Development of Neurorehabilitation Techniques Using Transcranial Magnetic Stimulation with Voluntary Muscle Contraction
$30.00
List Price: $37.50
Chapter 35
Masayuki Kitazawa
Recently, the physiological function of the human brain has become the subject of several investigations. Several methods have been developed to... Sample PDF
Development of Tactile Display Devices Using fMRI under High Magnetic Fields
$30.00
List Price: $37.50
Chapter 36
Shuxiang Guo, Zhibin Song
Strokes can lead to lasting neurological impairments. Many researchers are studying this process and have made important discoveries. Researchers... Sample PDF
Development of a Bilateral Assistance and Coordination Rehabilitation Training System
$30.00
List Price: $37.50
Chapter 37
Katsuhiro Nishino, Suguru Yamaguchi, Kousuke Matsuzono, Hiroyuki Yamamoto
The results showed that the range of motion (ROM) was improved in 6 out of 7 cases, while fine movement of the hand was also improved in 4 cases.... Sample PDF
The Use of Mesh Glove Neurostimulation for Motor Recovery in Chronic Stroke
$30.00
List Price: $37.50
Chapter 38
Akira Gyoten, Jinglong Wu, Satoshi Takahashi
Numerous therapeutic rehabilitation devices have been studied. This chapter describes novel rehabilitation devices designed to treat hand movement... Sample PDF
Novel Rehabilitation Devices for Hand Movement Disorders
$30.00
List Price: $37.50
Chapter 39
Naotsugu Kitayama, Haibo Wang, Satoshi Takahashi, Jinglong Wu
The purpose of this study was to develop a finger display device that has a four-degree-of-freedom (4DOF) length. This device was designed for... Sample PDF
A Novel Length Display Device for Cognitive Experiments and Rehabilitation
$30.00
List Price: $37.50
Chapter 40
Abdugheni Kutluk, Ryuji Nakamura, Toshio Tsuji, Teiji Ukawa, Noboru Saeki, Masao Yoshizumi, Masashi Kawamoto
This chapter proposes a new nonlinear model, called a log-linearized viscoelastic model, to estimate the dynamic characteristics of human arterial... Sample PDF
A Log-linearized Viscoelastic Model for Measuring Changes in Vascular Impedance
$30.00
List Price: $37.50
Chapter 41
Kazuya Funada, Jinglong Wu, Satoshi Takahashi
In rehabilitating hemiplegic patients, purposeful movements such as the opening and closing of hands are reported to be more effective than passive... Sample PDF
Surface EMG and Upper-Limb Rehabilitation
$30.00
List Price: $37.50
Chapter 42
Hirotoshi Yamamoto, Yasuyoshi Yokokohji, Hajime Takechi
In the area of welfare engineering, various technological research and developmental efforts have been made to support people with dementia.... Sample PDF
A Method for Eliciting the Support Needs from People with Early-Stage Dementia for Maintaining Social Living
$30.00
List Price: $37.50
Chapter 43
Mihoko Otake, Motoichiro Kato, Toshihisa Takagi, Hajime Asama
The causes of dementia are divided into genetic factors and cognitive factors. To prevent dementia by reducing the cognitive factors, the authors of... Sample PDF
The Coimagination Method and its Evaluation via the Conversation Interactivity Measuring Method
$30.00
List Price: $37.50
Chapter 44
Satoshi Takahashi, Jinglong Wu
The brief results of an international investigation of traffic accidents among aging people based on databases published by public institutions are... Sample PDF
An International Investigation of Driver’s Licenses for Dementia Patients with Considerations of Their Social Circumstances
$30.00
List Price: $37.50