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What is Afterload

Handbook of Research on Computational Grid Technologies for Life Sciences, Biomedicine, and Healthcare
In cardiovascular mechanics, is the myocardial wall stress during systolic ejection. If the muscle is allowed to shorten only after developing a certain force, this additional force is called afterload. Arterial input impedance is the ventricular afterload system. It influences, but is independent of, cardiac ejection of blood into the arterial vasculature and the resultant instantaneous pressure and volume of the ventricle. Instantaneous ventricular pressure and flow are the ventriculo-arterial coupling variables. The arterial input impedance is defined as the ratio of arterial pressure to arterial flow, both of which are measured at the root of the ascending aorta and expressed as a complex variable in the frequency domain. Mean arterial pressures can be considered as appropriate measures of ventricular afterload.
Published in Chapter:
Hybrid Mock Circulatory System to Test Cardiovascular Prostheses on the Grid
Francesco Maria Colacino (University Magna Graecia of Catanzaro and University of Calabria, Italy), Maurizio Arabia (University of Calabria, Italy), and Gionata Fragomeni (University Magna Graecia of Catanzaro, Italy)
DOI: 10.4018/978-1-60566-374-6.ch021
Abstract
In the last decades cardiovascular diseases greatly increased worldwide, and bioengineering provided new technologies and cardiovascular prostheses to medical doctors and surgeons. The design of active and passive devices aroused notable interests becoming more and more challenging as well as crucial. In this framework, it is important to faithfully reproduce the interaction between the prostheses and the cardiovascular system when in-vitro experiments are performed. For this reason, a new and improved kind of test benches becomes necessary. Purely hydraulic mock circulatory systems showed low flexibility to allow tests of different cardiovascular devices and low precision when a reference mathematical model must be reproduced. In this chapter a new bench is described. It combines the computer model of the cardiovascular system and its real-time interaction with the device to be tested. The solution adopted can be exploited in a Grid environment to allow remote experimentation.
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