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What is Missing Value Imputation

Chapter 18
Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications
The estimation of missing probe values for a gene by the expression of other probes over the rest of the slides, based on certain statistical or geometrical criteria.
Published in Chapter:
DNA Microarrays: Analysis and Interpretation
Aristotelis Chatziioannou (National Hellenic Research Foundation, Greece) and Panagiotis Moulos (National Hellenic Research Foundation, Greece)
Copyright: © 2009 |Pages: 16
DOI: 10.4018/978-1-60566-314-2.ch018
Abstract
The completion of the Human Genome Project and the emergence of high-throughput technologies at the dawn of the new millennium, are rapidly changing the way we approach biological problems. DNA microarrays represent a promising new technological development, widely used for the investigation and identification of genes associated with important biological processes. The chapter is divided in two parts: the first discusses current methods for the acquisition and quantitation of the microarray image while the second focuses in the analysis and interpretation of the microarray signals (standardization, normalization, statistical analysis etc.)
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