This chapter reports the results of a theoretical and practical research work on simulation, both as a teaching strategy that creates a dynamic and experiential situation which enables participants to take on roles in relation to the variables to be tested or modified, and the learning content that the students need to acquire. With reference to the training and educational needs of contemporary society, the theoretical premises underlying simulation are considered and examined in relation to recent findings regarding the process of learning and teaching and the acquisition of knowledge, as well as some recent research results. On the basis of the findings, it appears necessary to reflect on the synergy triggered through simulation. It particularly emphasized the role of simulation in the integration of different skills and types of knowledge, leading to the overcoming of the compartmentalization of knowledge and its fragmentation into discrete subjects or disciplines. Questions remain open regarding the role of ICT in the whole simulation process.