While we cannot predict the future, we can prepare for its potential outcome as best as we can. Knowledge and Education are our key facilitators (Fiorini, 2018; Ali, 2019; Kinsner, 2019). Therefore, we need to reframe uncertainty-as-problem in the past into the evolutive concept of uncertainty-as-resource for arbitrary multiscale system (Fiorini, 2019b; 2019c). The key change performance factors are knowledge and education, solving the major “information double-bind” (IDB) problem, just at the inner core of human knowledge extraction by experimentation in current science (Fiorini, 2015a). The new system must be based on an integrated approach; not only on the body of knowledge (BoK), but on the body of experience (BoX) too (Kinsner, 2019); not only on statistical algorithm, but on combinatorial one too, coupled together (Fiorini, 2016).