Bioinspired Nanoparticles for Efficient Drug Delivery System

Bioinspired Nanoparticles for Efficient Drug Delivery System

Basma Taqi Al-Najar (University of Bahrain, Bahrain) and Mohamed Bououdina (University of Bahrain, Bahrain)
Copyright: © 2016 |Pages: 35
DOI: 10.4018/978-1-4666-9811-6.ch003
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Abstract

Bioinspired nanoparticles have been involved in biomedicine field such as biosensors and drug delivery due to their small size and interesting characteristics that made them highly biocompatible, less toxic and hence greater influence on the biological systems. An effective drug delivery system can be achieved when applying these bioinspired material and herein we present several research work that involved bioinspired nanotechnology in drug delivery for cancer, therapeutic genes, calcium apatite nanocomposites, protein drugs and others.
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Introduction

Human biological system is made up of nanoscale particles that self-assembled to build biological tissues (Bhattacharya et al.,2014). It is well known that nanoparticles can be synthesized in several routes such as microwave, autoclave, sol-gel and other chemical routes resulting in different shapes and sizes. Hence, nanoparticles (NPs) has the suitable size to powerfully influence the biological systems, add to that their unique physical and chemical properties (Bhattacharya et al.,2014) .Therefore, NPs have been recently involved in a wide range of biomedical applications in particular biosensors (Bhattacharya,2014), biomolecular electronics (Bhattacharya et al.,2014) and drug delivery (Bhattacharya et al., 2014), (Thasneem et al., 2013) (Costa et al., 2014) (Peib et al., 2014). Today, NPs have been involved in the delivery of drugs for various sites and purposes including cancer therapy (Athinarayanan et al., 2015) Yigit et al., 2012) (Rena et al., 2013) (Ma'mani et al., 2014) (Jin et al., 2014) (Liechty et al., 2012), skin diseases (Tarl et al., 2011), heart diseases (Sylvester et al. 2013), ophthalmic disease (Jung et al., 2012) (Venkatesh et al., 2007), imaging purposes (Zhou et al., 2009)(Zhou et al., 2014), and gene delivery (Luvino et al., 2013).

During last decades, with the raise of advanced technologies, the synthesis of NPs has been developing rapidly allowing scientists to create advanced designs of nanoscale compounds that mimic natural systems in a very precise manner. Recently, bioinspired NPs have been applied in various biomedical applications and in particular in drug delivery. Most of these drugs delivered using a bioinspired design nanoscale compounds are cancer drugs. (Jin et al., 2014) reported the history of bioinspired NPs as a delivery vehicles of cancer drugs.

Natural nanocarriers that are found in biological systems circulating cargo in a prolonged and sustained manner have been the inspiration for researchers to design NPs that mimics the natural system (Chen et al., 2012) in uploading, delivering and releasing substances thereby apply this in drug delivery system (Yoo et al., 2011) (Wang Y. et al., 2014). Examples of natural nanocarriers are exosomes (Johnsen et al., 2014) (Stanley, 2014) (Johnsen et al., 2014), lipoprotiens (Stanley, 2014), Ferritin magnetites (Stanley, 2014), viruses (Stanley, 2014), extracellular vesicles (Meel et al., 2014), magnetic graphite (Ribeiro et al., 2014), microbes (Althuri et al., 2013) and self assembeled chitosan nanomaterials (Yang et al., 2014).

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