Controlled Drug Delivery Systems: Contemporary Significance and Advances – Overview and Advances for Controlled Drug Delivery Systems

Controlled Drug Delivery Systems: Contemporary Significance and Advances – Overview and Advances for Controlled Drug Delivery Systems

Shiv Shankar Shukla, Ravindra Kumar Pandey, Gunjan Kalyani
Copyright: © 2022 |Pages: 21
DOI: 10.4018/978-1-7998-8908-3.ch008
OnDemand:
(Individual Chapters)
Available
$37.50
Current Special Offers
No Current Special Offers
TOTAL SAVINGS: $37.50

Abstract

The drug delivery system allows the active pharmaceutical ingredient to be released in order to elicit the desired therapeutic response. Traditional drug delivery systems (tablets, capsules, syrups, ointments, etc.) have low bioavailability and are unable to produce continuous release due to changes in plasma drug levels. The therapeutic process can be rendered worthless without an effective delivery method. Furthermore, in order to achieve optimal efficacy and safety, the medicine must be administered at a precise controlled rate and to the target spot. Controlled drug delivery systems are being developed to address the issues with traditional drug delivery. Over the last two decades, there has been a great advancement in controlled drug delivery systems, ranging from macro to nanoscale to intelligent targeted delivery. This chapter covers the fundamentals of drug delivery systems, with a focus on the medication's pharmacokinetics and current major findings in controlled medication delivery.
Chapter Preview
Top

Design Considerations Of Controlled Release Drug Delivery Systems

Various elements and parameters must be addressed when building a controlled release medication delivery system. The metrics are divided into two categories:

  • •

    Formulation-related and

  • •

    Drug-related.

The biomaterial characteristics, mode of administration, pharmacokinetics, and stability enhancement are the most important formulation-related parameters. Furthermore, drug-related metrics such as drug binding effectiveness with plasma proteins and the drug's capacity to overcome biological barriers, as well as regulatory elements, are important considerations when determining the dosage form (Park, 2014).

Biomaterial features including biocompatibility, surface chemistry, hydrophilicity, degradation, and mechanical and rheological properties must all be investigated. In addition, the biomaterials' behaviour at various pH and temperature levels must be evaluated. When it comes to selecting the right biomaterial and developing the dosage form, the routes of drug administration are crucial.

Complete Chapter List

Search this Book:
Reset