Discovering Protein-Protein Interaction Sites from Sequence and Structure

Discovering Protein-Protein Interaction Sites from Sequence and Structure

David La (Purdue University, USA) and Daisuke Kihara (Purdue University, USA)
Copyright: © 2009 |Pages: 16
DOI: 10.4018/978-1-60566-398-2.ch005


This chapter gives a comprehensive introduction of the sequence/structural features that are characteristic of protein- protein interaction sites and reviews state-of-the-art methodologies for protein-protein binding site prediction. Protein-protein interaction residues are largely responsible for mediating physical binding processes such as inhibitory effects through enzyme-inhibitor interaction, initiating immune response by an antibody-antigen interaction, and regulation of cell signaling proteins. Currently, various methods are available for predicting protein-protein interaction sites, which allow a residue-level understanding of the physical protein binding phenomena presented by the global construction protein-protein interaction networks. The overview of the discussed protein-protein binding site prediction strategies and detailed comparison of their weaknesses and strengths is aimed towards assisting protein researchers in gaining more insight to protein-protein interaction networks.

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