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Sergey Petoukhov (Russian Academy of Sciences, Russia) and Matthew He (Nova Southeastern University, USA)

Source Title: Symmetrical Analysis Techniques for Genetic Systems and Bioinformatics: Advanced Patterns and Applications

Copyright: © 2010
|Pages: 24
DOI: 10.4018/978-1-60566-124-7.ch005

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TopThe universal genetic code may be viewed as the mapping of nucleic acids into polypeptides that is employed in every organism, organelle and virus with some minor variations. A mathematical view of genetic code is a map** g**:

We recall some basic definitions of a stochastic matrix. A square matrix of *P* = (*p _{ij}*) is a stochastic matrix if all entries of the matrix are nonnegative and the sum of the elements in each row (or column) is unity or a constant. If the sum of the elements in each row and column is unity or the same, the matrix is called doubly stochastic. The term “stochastic matrix” goes back at least to Romanovsky (1931). It plays a large role in the theory of discrete Markov chains. Stochastic matrices and doubly stochastic matrices have many remarkable properties. For example the Birkhoff–von Neumann Theorem says that every doubly stochastic matrix is a convex combination of permutation matrices of the same order and the permutation matrices are the extreme points of the set of doubly stochastic matrices. The properties of stochastic matrices are mainly spectral theoretic and are motivated by Markov chains. Doubly stochastic matrices have additional combinatorial structure.

The so called Gray code is one of the most famous in the theory of signal processing. The Gray code was used in a telegraph demonstrated by French engineer É. Baudot in 1878. The codes were first patented by F. Gray in 1953. The Gray code is a binary code in which consecutive decimal numbers are represented by binary expressions that differ in the state of one, and only one, bit. Gray codes have been extensively studied in other contexts. For example, Gray codes have been used in converting analog information to digital form. Here we review briefly how to construct a Gray code for each positive integer n. One way to construct a Gray code for n bits is to take a Gray code for (n-1) bits with each code prefixed by 0 (for the first half of the code) and append the (n-1) Gray code reversed with each code prefixed by 1 (for the second half). This is called a “binary-reflected Gray code”. Figure 1 is an example of creating a 3-bit Gray code from a 2-bit Gray code.

A Gray code representation of the genetic code was proposed in the work (Swanson, 1984). A representation of the genetic code as a six-dimensional Boolean hypercube was proposed in (Jimenéz-Montaño, Mora-Basáñez, & Pöschel, 1994). In (Štambuk, 2000), universal metric properties of the genetic code were defined by means of the nucleotide base representation on the square with vertices U or T = 0 0, C = 0 1, G = 1 0 and A = 1 1. It was shown that this notation defines the Cantor set and Smale horseshoe map representation of the genetic code. The “Biperiodic table of the genetic code” [C A; U G]^{(3)} (Figure 3 in Chapter 1), which has demonstrated an important symmetrical structure and has led to many discoveries, was introduced in (Petoukhov, 2001a, 2001b, 2005). This chapter describes stochastic characteristics of the biperiodic table on the basis of their original investigations and considerations in the works (He, 2001, 2003a, 2003b; He, Petoukhov, & Ricci, 2004).

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