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Top1. Introduction
While human exposure to radiation from different electromagnetic interference (EMI) sources has initiated a number of questions regarding potential adverse effects, particularly for the brain and eye exposure to high frequency (HF) radiation, some biomedical applications of electromagnetic fields are of particular importance, as well. Thus, the electromagnetic fields are applied in medical diagnostic and for therapy purposes featuring the use of techniques such as: transcranial magnetic stimulation (TMS) (Cvetković & et al., 2015; Garvey & Mall, 2008; Rajapakse & Kirton, 2013, Yamamoto & et al., 2016), percutaneous electrical nerve stimulation (PENS), transcutaneous nerve stimulation (TENS) (Frijnas & ten Kate, 1994; Rattay, 1999; Zulim & et al., 2015), or intraoperational methods such as transcranial electrical stimulation (TES) and direct cortical stimulation (DCS). Transcranial magnetic stimulation (TMS) is a noninvasive and painless technique for excitation or inhibition of brain regions, and in last few decades is an important tool in preoperative neurosurgical diagnostic/evaluation of patients (Picht & et al., 2013; Deletis & et al., 2014; Rogić & et al., 2014). TMS is also used in therapeutic purposes (i.e. depression), and is subject of interest in neurophysiologic research. Various efficiency aspects of TMS stimulation have been primarily stressed out primarily due to differences in relevant stimulation parameters such as pulse waveform, frequency, intensity of treatment, etc. The choice of optimal stimulation intensity is still investigated in many TMS studies.
The coil orientation and positioning appreciably influence the misalignment from the targeted brain region, thus reducing the TMS efficiency, although by using navigated TMS, this problem could be somewhat alleviated. In addition to the stimulation parameters, being adjustable to the requirements of the TMS operator, to a certain extent, the difference in individual brain morphology, due to age, gender or health status and the biological tissue parameters appreciably influence the distribution of the induced fields in the brain. Most of the parameters are obtained under different measurement on ex vivo animal and human tissues, and usually exhibit large variations from their average values. The level of uncertainty in the values of the brain conductivity and permittivity, is even more pronounced at low frequencies.
Modeling and computer simulation of TMS phenomena could be rather useful in determining the exact location of stimulation, in the interpretation of experimental results as well as in designing some more efficient stimulation setups. Realistic TMS models can also provide a more reliable prediction of the distribution of internal fields and currents by taking into account the variability of the various input parameters.