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Every seller is eager to make the full use of the exhibition opportunity of the front promotional webpage, but also bothered by its limited capacity. And for the large quantity of the candidate merchandise, how to select the most suitable goods to lay out in the front promotional webpage is the most prudent decision-making problem for the sellers. At the first sight, the goods with high earning power will be tended to display for maximum profit. But after our analyzing the e-commerce promotional characteristics, that is not the only one option. A lot of sellers want to take the competitive advantage of price discount in the promotional activities to meet their long-term goal, which is to dominate the market. At the same time, more and more sellers pay close attention to word-of-mouth advertising since it is the most beneficial. This finding can be explained by the possibility that customer satisfaction often generates free propaganda and saves subsequent marketing costs. As a consequence of the study, we think of the promotional goods selection problem from these three aspects. First, the earning power of the product is always the key factor that the sellers care about most. From an intuitive point of view, the earning power is that the sale price of this commodity subtracts all the cost of manufacturing, production, etc.. However, this is just the direct profit that can be seen in the e-commerce, but some products also have some other indirect profit. For example, if a commodity is sold, it has no effect on the sale of other goods, that is to say, its deal is in isolation. It only has its native profit because of no feedback and no return from others. While in many transactions, there exit a lot of cross selling (Brijs et al., 2000; Wong et al., 2003). In short, the purchase of commodity A would boost the same customer to buy commodity B in the same e-store. In this way, commodity A not only has its own original earning power, but also has derivative earning power which is reflected from the follow-up transactions. The original earning power and the derivative earning power are both considered in this paper. Second, there are always lots of price-sensitive consumers in the commercial activities (Maryam N. & Jamal S., 2010), and the price discount (Cheng, 2012) is also the focus of the promotional activities which is to highly attract customers' attention. The sellers are always prone to use the competitive price to get the large number of customer, and to dominate the market further. Third, the customer satisfaction is another hotspot issue we should think it over. Different from shopping in the traditional store, customer cannot touch or experience the goods from the e-store face to face, so the evaluation by the former buyers has been highlighted to a very important position. The customers pay close attention to the e-store’s reputation based on customer sentiment analysis (Zhang et al., 2012). Therefore, the mutual information in e-commerce becomes a core issue not only to the buyers but also to the sellers (Zhang et al., 2015; Zhang et al., 2015). As a consequence, the e-stores have to rack their brains to raise the reputation so that the customers would be attracted to the e-store and they could make up for the deficiency of missing the customers’ demand of live experience. In many business matters, the promotional merchandise selection strategy is a very complex problem that we should consider many relevant aspects of it. From our study, a description of the above three index analysis is demonstrated in the next part, and the corresponding mathematical model, called EPR (Earning power-Price discount-Reputation) model, is also established to obtain the optimal solution. And then an extended genetic algorithm is used to solve the model, and the validity of the method is shown by an experiment.