Nutraceuticals for Fibromyalgia and Neuropathic Pain

Nutraceuticals for Fibromyalgia and Neuropathic Pain

Garima Mishra, Pradeep Singh, Faheem Hyder Pottoo, Md Noushad Javed, Mulugeta Molla Zeleke, Yohannes Shumet Yimer
Copyright: © 2023 |Pages: 59
DOI: 10.4018/978-1-7998-4120-3.ch007
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Abstract

Both neuropathic pain and fibromyalgia are horrific painful conditions arising due to impairment in the somatosensory nervous system and the musculoskeletal system, respectively. They share some common symptoms like hyperalgesia, allodynia, insomnia, cognitive deficits, and mood disturbances. It is believed that fibromyalgia is the consequence of dysfunction of the central nervous system, autonomic nervous system, imbalance in neurotransmitters, and psychological and emotional stress. Henceforth, these pain syndromes have become a major challenge for healthcare professionals due to their complex etiology and poor availability and effectiveness of the drugs. Notably, the available synthetic drugs possess serious side effects including physical dependence and tolerance. Therefore, researchers are now seeking natural-based therapy for modulating chronic pain conditions. This chapter has been written with the intention of exploring the beneficial effects of various nutraceuticals including herbal dietary supplements in neuropathic pain and fibromyalgia.
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Types Of Neuropathic Pain

Depending on the origin, neuropathic pain is classified into two groups: peripheral and central as depicted in Figure 1. Peripheral neuropathy (PN) is the disorder related with dysfunction of peripheral nerves including sensory as well as motor neurons, axon and myelin of cell body. There are several etiological factors leading to peripheral neuropathy including metabolic, genetic, inflammation, traumatic etc. PN is primarily characterized by intense pain, muscle weakness, sensory loss (Marchettini, Lacerenza, Mauri, & Marangoni, 2006). Peripheral neuropathy involves ectopic neuronal activity in primary afferent nerves and in the dorsal root ganglion (DRG). The pathological mechanisms associated with peripheral neuropathy may be dysfunction of sodium channels, nociceptor sensitization, sympathetic sensory coupling and fiber interactions (Attal & Bouhassira, 1999).

Figure 1.

Types of neuropathic pain

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