Plant-Derived Bioactive Compounds: Promising Prospective Uses in the Chronic Inflammation

Plant-Derived Bioactive Compounds: Promising Prospective Uses in the Chronic Inflammation

Deepta Shirin S. P. Sundararajan Pushpalatha, Srinivasan Kumaraswamy, Ganesh Kumar Selvaraj, Radhakrishnan Narayanaswamy, Vasantha-Srinivasan Prabhakaran, Thangavel Sivakumar, Amala Kesavan
Copyright: © 2023 |Pages: 21
DOI: 10.4018/979-8-3693-0703-8.ch011
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Abstract

Inflammation is a robust immune response against exogenous stimulation processes like microbial invasion and physical injury. Despite inflammation being an essential host-defence mechanism, their chronic stage is highly associated with severe inflammatory disorders such as cancer and heart diseases. Natural bioactive compounds have been contributing a solid base for improving contemporary therapeutic agents against various inflammatory diseases. Due to their natural source and pharmacological benefits, medicinal plants have been utilized as a significant source of anti-inflammatory drugs. The plant's secondary metabolites, alkaloids, flavonoids, steroids, phenolics, tannins, and terpenoids play an essential role in the modulation of inflammatory responses. Those organic compounds reduce prolonged inflammation and represent a potential therapeutic entrant. The current book chapter describes various medicinal plants and their respective bioactive metabolites. Also, it represents their specific role to treat chronic inflammatory infections and disorders.
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Introduction

Inflammation is a molecular biological response of living organisms to a series of chemical, mechanical, and infectious microorganisms. The target is to destroy and segregate the invaded stimuli through localized protection (Benito et al., 2008). The effect of inflammation is controlled by the types and characterization of molecular triggers, which determine whether acute or chronic inflammation is in the biological system (Bertram et al., 2005; Benito et al., 2008; Ghasemi et al., 2018). The crucial disputes in treating these inflammatory diseases are their diversity and obstacle to the living body’s inflammatory system. These are mainly linked with the release of inflammatory cytokines and non-cytokines mediators such as reactive oxygen species (ROS) and nitric oxide (NO) (Li et al., 2012). Generally, these human inflammatory processes can end up in various chronic diseases, including cardiovascular diseases, diabetes, dementia, and cancer. Several treatment strategies are in the medical trials to prevent these chronic inflammation stages. Among those strategies, herbs and spices-derived organic phytochemicals have long been used as an essential therapeutic tool due to their reputed medicinal effects on anti-inflammation (Assaggaf et al., 2022; Baker et al., 2020; Kuete, 2014; Sandoval, 2002). Here, we elaborate on the organic phytochemicals that possess anti-inflammatory effects on living organisms. The currently proposed book chapter is a keynote to develop new organic drugs to manage many inflammatory diseases.

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