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Use of Lipids, Polymers, and Peptides for Drug Delivery and Targeting to Cancer Cells or Specific Organs

Use of Lipids, Polymers, and Peptides for Drug Delivery and Targeting to Cancer Cells or Specific Organs

Sampan Attri (Department of Community Medicine and School of Public Heath, PGIMER, India), Shruti Sharma (Department of Experimental Medicine and Biotechnology, PGIMER, India), Ujjawal Sharma (Department of Community Medicine and School of Public Heath, PGIMER, India), Manjita Srivastava (National Institute of Virology (ICMR), India), Subash C. Sonkar (Multidisciplinary Research Unit, Department of Biochemistry, New Delhi, India), Meenakshi Singh (Transplant Immunology and Immunogenetics Lab (HLA), ACTREC, Tata Memorial Centre, India), and Prudhvilal Bhukya (National Institute of Virology (ICMR), Pune, India)
Copyright: © 2021 |Pages: 14
DOI: 10.4018/978-1-7998-6530-8.ch008
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Abstract

Cancer has been the most deleterious disease in recent times, and unfortunately its spread is increasing. Systemic treatment with chemotherapeutics remains the conventional way of treating many cancers, despite the serious damage long-term chemotherapy can cause in healthy tissues. Many therapeutic strategies have achieved popular practical applications, but drug delivery systems still face challenges associated with safety, and this has led to the development of safer drug delivery methods composed of biocompatible substances. In this respect, lipid-, polymer-, and peptide-based drug delivery systems have been proposed as safer candidates for cancer therapy. These delivery methods are expected to as biodegradable systems with low cytotoxicity for cancer therapy. Therefore, in this chapter, the authors discuss use of lipids, polymers, and peptides as delivery vehicles for chemotherapeutic agents and their structural characteristics.
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Liposomes

One of the most efficient drug delivery systems for disease treatment, are Liposomes. Liposomes are spherical vesicles of phospholipid bilayer enclosing a water droplet (Figure 1), especially designed artificially to act as a vehicle for drugs or other substances transportation into the tissues. These systems have unique properties such as smaller size, biocompatibility, biodegradability, low toxicity hydrophobic and hydrophilic character, and immunogenicity that result in significant efficiency on cancer therapy (Zhang and Huang, 2020).

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