It refers to the situation where bacteria no longer get destroyed in the presence of antibiotics.
Recent Strategies Inhibiting Quorum Sensing and Biofilm Formation in Bacteria to Combat Antibacterial Drug Resistance
Sakshi Tiwari (University Institute of Pharmacy, Pt. Ravishankar Shukla University, India), Swagata Deshpande (University Institute of Pharmacy, Pt. Ravishankar Shukla University, India), Bina Gidwani (Columbia Institute of Pharmacy, India), Reena Gupta (Institute of Pharmaceutical Research, GLA University, India),
Kapil Agrawal (R.C. Patel Institute of Pharmaceutical Education and Research, India), Veenu Joshi (Centre for Basic Science, Pt. Ravishankar Shukla University, India), Neelu Joshi (School of Biotechnology and Bioinformatics, D.Y. Patil University, India), Vishal Jain (University Institute of Pharmacy, Pt. Ravishankar Shukla University, India),
Preeti K. Suresh (University Institute of Pharmacy, Pt. Ravishankar Shukla University, India), and
Amber Vyas (University Institute of Pharmacy, Pt. Ravishankar Shukla University, India)
Antibacterial drug resistance is a global issue that arises as bacteria adapt over time to certain medications, making illnesses more difficult to cure and raising the possibility of contracting a disease, getting sick, or possibly dying. Quorum-sensing communication routes are used by bacteria to control a variety of physiological processes and it relies on bacterial receptors, which are manufactured by bacteria, to recognize small signaling molecules called autoinducers. The activation of the genes necessary for biofilm formation occurs when autoinducers bind to receptors. The purpose and concentration of the chapter is to comprehend the process underlying the development of biofilms brought on by the quorum sensing system, which gives both gram-positive and negative microorganisms resistance to antibacterial medications. It also examines recent developments and strategies for bacterial biofilm breakdown with an emphasis on quorum-sensing inhibitors.