A gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor.
Published in Chapter:
Integration of Clinical and Genomic Data for Decision Support in Cancer
Yorgos Goletsis (University of Ioannina, Greece), Themis P. Exarchos (University of Ioannina, Greece), Nikolaos Giannakeas (University of Ioannina, Greece), Markos G. Tsipouras (University of Ioannina, Greece), and Dimitrios I. Fotiadis (University of Ioannina, Greece, and Michaelideion Cardiology Center, Greece & Biomedical Research Institute, Greece)
Copyright: © 2008
|Pages: 9
DOI: 10.4018/978-1-59904-889-5.ch097
Abstract
In this article, we address decision support for cancer by exploiting clinical data and identifying mutations on tumour suppressor genes. The goal is to perform data integration between medicine and molecular biology by developing a framework where clinical and genomic features are appropriately combined in order to handle cancer diseases. The constitution of such a decision support system is based on (a) cancer clinical data and (b) biological information that is derived from genomic sources. Through this integration, real time conclusions can be drawn for early diagnosis, staging and more effective cancer treatment.