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What is Ubiquitin-Proteasomal System

Principles and Clinical Interventions in Social Cognition
A crucial cellular mechanism that directs the targeted degradation of particular proteins inside the cell. It regulates the course of the cell cycle, apoptosis, a mechanism of regulated cell death, and the removal of misfolded or damaged proteins, among other cellular processes. The targeted protein is marked for breakdown in this process by the attachment of ubiquitin, a tiny regulatory protein. The proteasome, a sizable protein complex in charge of protein degradation in cells, then recognizes and degrades the tagged protein. The ubiquitin-proteasomal system plays a crucial role in the immunological response, neurological illnesses, cancer, and other critical biological processes. It is also necessary for preserving the proper balance of proteins inside the cell.
Published in Chapter:
Social Cognitive Rehabilitation for Neurodegenerative Disorders
S. Meghana (National Institute of Advanced Studies, Bengaluru, India) and Sakshi Shishir (Christ University, India)
Copyright: © 2024 |Pages: 19
DOI: 10.4018/979-8-3693-1265-0.ch016
Abstract
In this chapter, an initial exploration of the definition and symptoms of neurodegenerative disorders will be conducted along with an in-depth analysis of their underlying neurobiological basis, shedding light on their manifestation in the brain. The central focus will then shift towards comprehending and addressing the specific social cognitive deficits associated with different types of NDs and examining the challenges posed in the realm of social cognition. Strategies and interventions specifically designed for social cognitive rehabilitation will be investigated. The chapter will encompass a discussion on the caregiver burden and effective coping strategies to alleviate the stresses faced. The primary objective of this chapter is to provide readers with a comprehensive understanding of the intricate nature of social cognitive deficits in neurodegenerative disorders and equip them with practical tools aimed at enhancing social cognition and improving the quality of life for individuals affected by these complex conditions.
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