Call for Chapters: The Multifactorial Etiology of Congenital Heart Disease: Insights from Teratology, Genetics, and Exposomics

Editors

Ramya Raghavan, Sri Sathya Sai University for Human Excellence, India

Call for Chapters

Proposals Submission Deadline: July 1, 2025
Full Chapters Due: August 27, 2025
Submission Date: August 27, 2025

Introduction

Congenital Heart Disease (CHD) remains one of the most prevalent and challenging congenital anomalies, affecting approximately 1% of all live births worldwide. The etiology of CHD is complex, involving an intricate interplay of genetic, environmental, and exposomic factors. This book aims to provide a comprehensive exploration of the teratogenic, genetic, and exposomic influences on the development of both syndromic and non-syndromic CHD, addressing existing knowledge gaps and presenting cutting-edge research in this rapidly evolving field.

Objective

The book will explore the historical perspective on CHD etiology, tracing the evolution of our understanding from purely genetic models to the current multifactorial paradigm. A significant portion of the book will be dedicated to exploring the non-genetic factors underlying CHD. The exposomic perspective on CHD development will be a key focus of the book, reflecting the growing recognition of the importance of environmental influences on fetal cardiovascular development. The book will also delve into the complex genetic landscape of non-syndromic CHD, while discussing monogenic models, genetic heterogeneity, and the emerging understanding of polygenic and oligogenic contributions to CHD risk. The book chapters will present recent advances in high-resolution metabolomics and the integration of omics technologies, highlighting their potential to uncover complex gene-environment interactions in CHD etiology. Contents will address the challenges and opportunities in translating research findings into clinical practice, including the potential for personalized prevention and treatment strategies based on individual genetic and exposomic profiles.

Target Audience

Researchers and academics in genetics, teratology, and environmental health Pediatric cardiologists and allied healthcare professionals Public health professionals interested in CHD prevention and risk assessment Graduate students and postdoctoral researchers in related fields Genetic counselors and prenatal care specialists

Recommended Topics

• Etiological distinction in Syndromic vs. non-syndromic CHD • Teratogenic Factors in CHD Development • Rubella, Alcohol, PAH, plastics, VOCs, infection, radiation • Environmental Metabolism Disrupting Chemicals • Metabolic Memory: Focus on Mitochondrial Function • Medication-induced CHD: Lithium, retinoic acid, and anticonvulsants • Environmental teratogens: Industrial, occupational exposure, Pollutants and toxicants • Toxicology and Toxicogenomics: Paternal Occupational conditions and medications • Social determinants: Infectious diseases, Nutritional factors and maternal diet • Hazard ratios of lifestyle and Occupational pollutants and toxicants • Geo-Spatial Analysis, Congenital Tumors, and Early life fetal Exposures • Noonan syndrome, Alagille syndrome, and Holt-Oram syndrome • Genetic testing and counseling in syndromic CHD • Non-syndromic CHD, monogenic models, genetic heterogeneity • Chromosomal aneuploidies, CNVs, 22q11.2 and deletion syndromes • Polygenic and oligogenic contributions to CHD risk. • Reproductive toxicants, Endocrine Disruptors • Epigenetic mechanisms in CHD development • Monogenic models of non-syndromic CHD • Genetic heterogeneity in isolated CHD • Advanced Technologies in CHD Research • Innovations in Omics, Nanotechnology, and Synthetic Biology • Omics-Driven Insights, Emerging Nano-Bio Technologies in Maternal-Fetal Health • Synthetic and Nano-Enabled Diagnostics • Prenatal Multi-Omics for Environmental Triggers • Spatial Transcriptomics and Epigenomics in Mapping Fetal heart • Single-Cell Omics in Heart Morphogenesis • Advanced Experimental Models • Synthetic Gene Circuits for Environmental Sensing • Programmable Cellular Systems, Synthetic Bioswitches • Next-Generation Technologies in Congenital Heart Exposomics • Embryonic Cardiac Models • Cell-Free Synthetic Platforms • Environmental Biosensing • Nanotechnology-Enabled Monitoring and Intervention • Smart Nanosensors for Cardiac Teratogens • Nanoparticle-Enabled Biosensors for Oxidative Stress and Inflammation • Nano-Delivered Prenatal Therapeutics • Nanostructured Hydrogels for Controlled Delivery • Fetal Heart Organoids • Bioengineered Cardiac Constructs • Synthetic Microbiomes Modulation • Lab-on-a-Chip Platforms • Prenatal Ethics in Synthetic Biology • Regulation of Emerging Prenatal Technologies • Global Equity and Access in CHD Tech • Regulatory Frameworks for Clinical Translation • Global Health Perspectives and Technologies CHD Prevention • ncRNAs and miRNAs in germ cell differentiation • Postnatal exposure metabolomics adductomics • Bioinformatics Exposome-wide association studies (ExWAS) • Biomarkers: Advances in genetic testing • Risk Factors in Per- and poly-fluoroalkyl substances • Maternal phenylketonuria (PKU), Age: Separating direct and indirect effects • Congenital anomaly, CHD-cancer associations • Monozygotic twinning, Chorionicity in twin pregnancies • Assisted reproductive technologies and CHD risk in multiple births • Artificial intelligence and Machine learning Applications • High-resolution metabolomics using Saliva, Urine for early detection • Integrating exposomics with genomics and epigenomics • Proteomics Metabolomics and Systems biology approaches • Public health Policies in CHD Risk Assessment and Prevention • Preconception and prenatal screening for CHD risk factors • Fetal echocardiography Translating Research into Clinical Practice

Submission Procedure

Researchers and practitioners are invited to submit on or before July 1, 2025, a chapter proposal of 1,000 to 2,000 words clearly explaining the mission and concerns of his or her proposed chapter. Authors will be notified by July 14, 2025 about the status of their proposals and sent chapter guidelines. Full chapters of a minimum of 10,000 words (word count includes references and related readings) are expected to be submitted by August 27, 2025, and all interested authors must consult the guidelines for manuscript submissions at https://www.igi-global.com/publish/contributor-resources/before-you-write/ prior to submission. All submitted chapters will be reviewed on a double-anonymized review basis. Contributors may also be requested to serve as reviewers for this project.

Note: There are no submission or acceptance fees for manuscripts submitted to this book publication, The Multifactorial Etiology of Congenital Heart Disease: Insights from Teratology, Genetics, and Exposomics. All manuscripts are accepted based on a double-anonymized peer review editorial process.

All proposals should be submitted through the eEditorial Discovery^® online submission manager.

Publisher

This book is scheduled to be published by IGI Global Scientific Publishing (formerly Idea Group Inc.), an international academic publisher of the "Information Science Reference" (formerly Idea Group Reference), "Medical Information Science Reference," "Business Science Reference," and "Engineering Science Reference" imprints. IGI Global Scientific Publishing specializes in publishing reference books, scholarly journals, and electronic databases featuring academic research on a variety of innovative topic areas including, but not limited to, education, social science, medicine and healthcare, business and management, information science and technology, engineering, public administration, library and information science, media and communication studies, and environmental science. For additional information regarding the publisher, please visit https://www.igi-global.com. This publication is anticipated to be released in 2026.

Important Dates

July 1, 2025: Proposal Submission Deadline
July 14, 2025: Notification of Acceptance
August 27, 2025: Full Chapter Submission
September 7, 2025: Review Results Returned
October 5, 2025: Final Acceptance Notification
October 12, 2025: Final Chapter Submission

Inquiries

Ramya Raghavan
Sri Sathya Sai University for Human Excellence
ramya.saivrinda@gmail.com

Classifications

Computer Science and Information Technology; Life Sciences; Medicine and Healthcare; Physical Sciences and Engineering

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