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What is Meta-Analysis

Chapter 18

Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications

The exhaustive search process which comprises numerous and versatile algorithmic procedures to exploit the gene expression results by combining or further processing them with sophisticated statistical learning and data mining techniques coupled with annotated information concerning functional properties of these genes residing in large databases.

Published in Chapter:

DNA Microarrays: Analysis and Interpretation

Aristotelis Chatziioannou (National Hellenic Research Foundation, Greece) and Panagiotis Moulos (National Hellenic Research Foundation, Greece)

Source Title: Handbook of Research on Advanced Techniques in Diagnostic Imaging and Biomedical Applications

DOI: 10.4018/978-1-60566-314-2.ch018

Abstract

The completion of the Human Genome Project and the emergence of high-throughput technologies at the dawn of the new millennium, are rapidly changing the way we approach biological problems. DNA microarrays represent a promising new technological development, widely used for the investigation and identification of genes associated with important biological processes. The chapter is divided in two parts: the first discusses current methods for the acquisition and quantitation of the microarray image while the second focuses in the analysis and interpretation of the microarray signals (standardization, normalization, statistical analysis etc.)